Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 10/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.45 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.45 |
| ▸ | RELA | Q04206 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6987967 | 0.91 | MAPK10 (0.52) | TGFBR1MEN1KMT2AMAPK14NPC1 | |
| SCHEMBL6998890 | 0.89 | TGFBR1 (0.55) | TGFBR1MAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL4036011 | 0.87 | TGFBR1 (0.63) | TGFBR1MAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL7001195 | 0.84 | KDR (0.46) | TGFBR1MEN1KMT2AMAPK14GAA | |
| SCHEMBL6994559 | 0.82 | TGFBR1 (0.44) | TGFBR1MEN1KMT2AMAPK14NPC1 | |
| SCHEMBL4035730 | 0.80 | TGFBR1 (0.52) | TGFBR1MAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL5956505 | 0.79 | TGFBR1 (0.55) | TGFBR1MAPTMEN1KMT2AMAPK14 | |
| SCHEMBL18236266 | 0.77 | TGFBR1 (0.60) | TGFBR1MAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL413765 | 0.76 | TGFBR1 (0.52) | TGFBR1MAPTMEN1KMT2AMAPK14 | |
| SCHEMBL415611 | 0.76 | TGFBR1 (0.52) | TGFBR1MAPTMAPK14ALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1366047-A1 | THIAZOLE COMPOUNDS AS TGF-BETA INHIBITORS | GLAXO GROUP LIMITED (GB) | 2003-12-03 | — | — | EP | claimed |
| WO-2002062793-A1 | THIAZOLE COMPOUNDS AS TGF-BETA INHIBITORS | GLAXO GROUP LIMITED (GB) | 2002-08-15 | — | — | WO | claimed |
| EP-1366047-A1 | THIAZOLE COMPOUNDS AS TGF-BETA INHIBITORS | GLAXO GROUP LIMITED (GB) | 2003-12-03 | — | — | EP | disclosed |
| WO-2002062793-A1 | THIAZOLE COMPOUNDS AS TGF-BETA INHIBITORS | GLAXO GROUP LIMITED (GB) | 2002-08-15 | — | — | WO | disclosed |