Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | VDR | P11473 | 2/20 | 0.52 |
| ▸ | IDO1 | P14902 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | CTSV | O60911 | 1/20 | 0.49 |
| ▸ | CTSL | P07711 | 1/20 | 0.49 |
| ▸ | AR | P10275 | 1/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.48 |
| ▸ | MMP2 | P08253 | 1/20 | 0.48 |
| ▸ | MMP9 | P14780 | 1/20 | 0.48 |
| ▸ | MMP8 | P22894 | 1/20 | 0.48 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | SLC11A2 | P49281 | 1/20 | 0.45 |
| ▸ | FASN | P49327 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14023439 | 0.82 | MAPK14 (0.52) | MEN1GAAKMT2ALMNAVDR | |
| SCHEMBL16454839 | 0.82 | ESR1 (0.67) | MEN1KMT2AIDO1MAPTPTGS2 | |
| SCHEMBL8722219 | 0.81 | IMPDH2 (0.52) | IMPDH2MEN1KMT2ALMNAMAPT | |
| SCHEMBL12561646 | 0.80 | MAPK14 (0.53) | MEN1GAAKMT2ALMNAIDO1 | |
| SCHEMBL16169793 | 0.79 | IMPDH2 (0.69) | IMPDH2MEN1GAAKMT2ALMNA | |
| SCHEMBL27717136 | 0.78 | IDO1 (0.48) | MEN1KMT2ALMNAIDO1MAPT | |
| SCHEMBL17383846 | 0.78 | IMPDH2 (0.73) | IMPDH2MEN1GAAKMT2ALMNA | |
| Carbazole SCHEMBL27552113 | 0.78 | CTSV (0.67) | MEN1GAAKMT2ALMNAVDR | |
| SCHEMBL19389307 | 0.78 | MAPK14 (0.48) | MEN1GAAKMT2ALMNAVDR | |
| SCHEMBL3881804 | 0.77 | MAP2 (0.69) | MEN1GAAKMT2AIDO1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1303508-A1 | SUBSTITUTED 1-(4-AMINOPHENYL)INDOLES AND THEIR USE AS ANTI-INFLAMMATORY AGENTS | Boehringer Ingelheim Pharmaceuticals, Inc. (US) | 2003-04-23 | — | — | EP | disclosed |
| WO-2002006273-A1 | SUBSTITUTED 1-(4-AMINOPHENYL)INDOLES AND THEIR USE AS ANTI-INFLAMMATORY AGENTS | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2002-01-24 | — | — | WO | disclosed |