Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | MTOR | P42345 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.57 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | GMNN | O75496 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | BLM | P54132 | 1/20 | 0.56 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5053564 | 0.85 | CYP19A1 (0.72) | CYP1A2CYP3A4CYP2D6MAPTCYP19A1 | |
| SCHEMBL11232092 | 0.81 | CYP19A1 (0.55) | MAPTCYP19A1ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL14416013 | 0.81 | CHRM2 (0.60) | TSHRRAB9AKMT2AMEN1MAPT | |
| SCHEMBL11236509 | 0.81 | ALDH1A1 (0.55) | RAB9AMAPTLMNACYP19A1ALDH1A1 | |
| SCHEMBL6987181 | 0.81 | CYP11B1 (0.72) | CYP1A2CYP3A4CYP2D6CYP2C9TSHR | |
| SCHEMBL14464749 | 0.80 | ALDH1A1 (0.50) | CYP1A2CYP3A4CYP2D6CYP2C9TSHR | |
| SCHEMBL27508985 | 0.78 | CYP11B1 (0.51) | CYP1A2CYP3A4CYP2D6KMT2AMAPT | |
| SCHEMBL6988826 | 0.78 | CYP11B1 (0.72) | CYP1A2CYP3A4CYP2D6KMT2AMEN1 | |
| SCHEMBL6991263 | 0.78 | CYP11B1 (0.72) | HMOX1CYP19A1QPCT | |
| SCHEMBL1719741 | 0.78 | CYP11B1 (0.72) | HMOX1CYP19A1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0588858-B1 | IMIDAZO 2,1-b] 3]BENZAZEPINE DERIVATIVES, COMPOSITIONS AND METHOD OF USE | JANSSEN PHARMACEUTICA NV (BE) | 2003-09-17 | — | — | EP | disclosed |
| CN-1070368-C | A method for preparing a medical composition conpaining imidazo[2,1-b][3] benzo azepine dericvants | JANSSEN PHARMACEUTICA NV (BE) | 2001-09-05 | — | — | CN | disclosed |
| CN-1142360-A | A method for preparing a medical composition conpaining imidazo[2,1-b][3] benzo azepine dericvants | YUAN ANLING (CN) | 1997-02-12 | — | — | CN | disclosed |
| US-5468743-A | Imidazo[2,1-b]benzazepine derivatives, compositions and method of use | JANSSEN PHARMACEUTICA N.V. (BE) | 1995-11-21 | — | — | US | disclosed |
| EP-0588858-A1 | IMIDAZO 2,1-b] 3]BENZAZEPINE DERIVATIVES, COMPOSITIONS AND METHOD OF USE | JANSSEN PHARMACEUTICA N.V. (BE) | 1994-03-30 | — | — | EP | disclosed |
| WO-1992022551-A1 | IMIDAZO[2,1-b][3]BENZAZEPINE DERIVATIVES, COMPOSITIONS AND METHOD OF USE | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-12-23 | — | — | WO | disclosed |
| EP-0518435-A1 | Imidazo[2,1-b][3]benzazepine derivatives, compositions and method of use | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-12-16 | — | — | EP | disclosed |