Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 8/20 | 0.51 |
| ▸ | CYP11B2 | P19099 | 8/20 | 0.51 |
| ▸ | HMOX1 | P09601 | 1/20 | 0.51 |
| ▸ | TBXAS1 | P24557 | 4/20 | 0.48 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | QPCT | Q16769 | 1/20 | 0.47 |
| ▸ | CYP4Z1 | Q86W10 | 1/20 | 0.47 |
| ▸ | QPCTL | Q9NXS2 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27460992 | 0.87 | TBXAS1 (0.60) | CYP11B1CYP11B2HMOX1TBXAS1CYP19A1 | |
| SCHEMBL24733003 | 0.84 | CYP11B1 (0.71) | CYP11B1CYP11B2TBXAS1CYP19A1ADRA2C | |
| SCHEMBL6991263 | 0.81 | CYP11B1 (0.72) | CYP11B1CYP11B2HMOX1TBXAS1CYP19A1 | |
| SCHEMBL6988826 | 0.81 | CYP11B1 (0.72) | CYP11B1CYP11B2HMOX1TBXAS1CYP19A1 | |
| SCHEMBL6987181 | 0.81 | CYP11B1 (0.72) | CYP11B1CYP11B2HMOX1TBXAS1CYP19A1 | |
| SCHEMBL1719741 | 0.81 | CYP11B1 (0.72) | CYP11B1CYP11B2HMOX1CYP19A1ADRA2C | |
| SCHEMBL409741 | 0.80 | HMOX1 (0.72) | CYP11B1CYP11B2HMOX1TBXAS1CYP19A1 | |
| Bromide SCHEMBL29223796 | 0.78 | HMOX1 (0.70) | CYP11B1CYP11B2HMOX1TBXAS1CYP19A1 | |
| Hydrochloric Acid SCHEMBL7527357 | 0.78 | HMOX1 (0.70) | CYP11B1CYP11B2HMOX1TBXAS1CYP19A1 | |
| SCHEMBL6989098 | 0.78 | TP53 (0.57) | HMOX1CYP19A1KMT2ACYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1070368-C | A method for preparing a medical composition conpaining imidazo[2,1-b][3] benzo azepine dericvants | JANSSEN PHARMACEUTICA NV (BE) | 2001-09-05 | — | — | CN | disclosed |
| CN-1033586-C | Imidazo [2, 1-b ] [3] benzazepine derivatives and their use as anti-inflammatory agents | JANSSEN PHARMACEUTICA NV (BE) | 1996-12-18 | — | — | CN | disclosed |
| CN-1068118-A | Imidazo [2, 1-b ] [3] benzazepine derivatives, compositions and methods of use | JANSSEN PHARMACEUTICA NV (BE) | 1993-01-20 | — | — | CN | disclosed |