Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 5/20 | 0.72 |
| ▸ | CYP11B2 | P19099 | 5/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | HMOX1 | P09601 | 1/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12205 | 0.84 | CYP11B1 (1.00) | CYP11B1CYP11B2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL27508985 | 0.81 | CYP11B1 (0.51) | CYP11B1CYP11B2KMT2ACYP1A2CYP3A4 | |
| SCHEMBL6991263 | 0.81 | CYP11B1 (0.72) | CYP11B1CYP11B2HMOX1CYP19A1TBXAS1 | |
| SCHEMBL1719741 | 0.81 | CYP11B1 (0.72) | CYP11B1CYP11B2HMOX1CYP19A1 | |
| SCHEMBL6988826 | 0.81 | CYP11B1 (0.72) | CYP11B1CYP11B2KMT2ACYP1A2CYP3A4 | |
| SCHEMBL6989098 | 0.81 | TP53 (0.57) | KMT2ACYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL6987156 | 0.80 | CYP19A1 (0.69) | CYP11B1CYP11B2KMT2AHMOX1CYP19A1 | |
| SCHEMBL409741 | 0.80 | HMOX1 (0.72) | CYP11B1CYP11B2KMT2ACYP1A2CYP3A4 | |
| SCHEMBL11229525 | 0.79 | CYP11B1 (0.60) | CYP11B1CYP11B2KMT2ACYP1A2CYP3A4 | |
| SCHEMBL14492302 | 0.79 | CYP11B1 (0.60) | CYP11B1CYP11B2KMT2ACYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0588858-B1 | IMIDAZO 2,1-b] 3]BENZAZEPINE DERIVATIVES, COMPOSITIONS AND METHOD OF USE | JANSSEN PHARMACEUTICA NV (BE) | 2003-09-17 | — | — | EP | disclosed |
| US-5468743-A | Imidazo[2,1-b]benzazepine derivatives, compositions and method of use | JANSSEN PHARMACEUTICA N.V. (BE) | 1995-11-21 | — | — | US | disclosed |
| EP-0588858-A1 | IMIDAZO 2,1-b] 3]BENZAZEPINE DERIVATIVES, COMPOSITIONS AND METHOD OF USE | JANSSEN PHARMACEUTICA N.V. (BE) | 1994-03-30 | — | — | EP | disclosed |
| WO-1992022551-A1 | IMIDAZO[2,1-b][3]BENZAZEPINE DERIVATIVES, COMPOSITIONS AND METHOD OF USE | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-12-23 | — | — | WO | disclosed |
| EP-0518435-A1 | Imidazo[2,1-b][3]benzazepine derivatives, compositions and method of use | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-12-16 | — | — | EP | disclosed |