Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | RAD52 | P43351 | 1/20 | 0.31 |
| ▸ | CLK1 | P49759 | 1/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5848261 | 0.70 | KDM4E (0.33) | KDM4E | |
| SCHEMBL6989148 | 0.70 | LMNA (0.31) | KDM4E | |
| SCHEMBL25629 | 0.64 | KDM4E (0.41) | KDM4EPOLBHTTRAD52CLK1 | |
| SCHEMBL25666731 | 0.61 | LMNA (0.47) | KDM4EPOLBHTTRAD52CLK1 | |
| SCHEMBL10902378 | 0.61 | CYP11B1 (0.51) | KDM4EPOLBHTT | |
| SCHEMBL16837159 | 0.60 | KDM4E (0.38) | KDM4EPOLBHTTRAD52CLK1 | |
| SCHEMBL28035479 | 0.60 | HTT (0.35) | KDM4EPOLBHTTRAD52CLK1 | |
| SCHEMBL16417585 | 0.60 | MAOA (0.37) | KDM4EPOLBHTTRAD52CLK1 | |
| SCHEMBL376002 | 0.60 | TNF (0.40) | KDM4EPOLBHTTRAD52 | |
| SCHEMBL29903165 | 0.60 | TNF (0.40) | KDM4EPOLBHTTRAD52 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6906068-B1 | Substituted polycyclic aryl and heteroaryl 1,2,4 - triazinones useful as anticoagulants | PHARMACIA CORPORATION (US) | 2005-06-14 | — | — | US | disclosed |
| EP-1292579-A1 | SUBSTITUTED POLYCYCLIC ARYL AND HETEROARYL PYRAZINONES USEFUL FOR SELECTIVE INHIBITION OF THE COAGULATION CASCADE | Pharmacia Corporation (US) | 2003-03-19 | — | — | EP | disclosed |
| WO-2001087854-A1 | SUBSTITUTED POLYCYCLIC ARYL AND HETEROARYL PYRAZINONES USEFUL FOR SELECTIVE INHIBITION OF THE COAGULATION CASCADE | PHARMACIA CORPORATION (US) | 2001-11-22 | — | — | WO | disclosed |