Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | PRNP | P04156 | 1/20 | 0.49 |
| ▸ | FNTA | P49354 | 2/20 | 0.48 |
| ▸ | FNTB | P49356 | 2/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | TUBB4A | P04350 | 3/20 | 0.40 |
| ▸ | TUBB | P07437 | 3/20 | 0.40 |
| ▸ | TUBA3C | P0DPH7 | 3/20 | 0.40 |
| ▸ | TUBA1B | P68363 | 3/20 | 0.40 |
| ▸ | TUBA4A | P68366 | 3/20 | 0.40 |
| ▸ | TUBB4B | P68371 | 3/20 | 0.40 |
| ▸ | TUBB3 | Q13509 | 3/20 | 0.40 |
| ▸ | TUBB2A | Q13885 | 3/20 | 0.40 |
| ▸ | TUBB8 | Q3ZCM7 | 3/20 | 0.40 |
| ▸ | TUBA3E | Q6PEY2 | 3/20 | 0.40 |
| ▸ | TUBA1A | Q71U36 | 3/20 | 0.40 |
| ▸ | TUBA1C | Q9BQE3 | 3/20 | 0.40 |
| ▸ | TUBB6 | Q9BUF5 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7495375 | 0.83 | HTR2A (0.58) | MAPTPRNPDRD2HTR2AHTR2C | |
| SCHEMBL6992348 | 0.81 | TUBB4A (0.57) | MAPTPRNPDRD2HTR2AHTR2C | |
| SCHEMBL5774983 | 0.78 | MAPT (0.51) | MAPTPRNPDRD2HTR2AHTR2C | |
| SCHEMBL6990745 | 0.77 | DRD2 (0.52) | MAPTPRNPDRD2HTR2AHTR2C | |
| SCHEMBL6990227 | 0.76 | MAPT (0.47) | MAPTPRNPDRD2HTR2AHTR2C | |
| SCHEMBL28804560 | 0.76 | MAPT (0.49) | MAPTPRNPDRD2HTR2AHTR2C | |
| SCHEMBL6824403 | 0.76 | KDM4E (0.59) | MAPTFNTAFNTBALDH1A1KDM4E | |
| SCHEMBL11495737 | 0.76 | CYP3A4 (0.59) | MAPTFNTAFNTBDRD2HTR2A | |
| SCHEMBL6993933 | 0.76 | MAPT (0.49) | MAPTPRNPDRD2HTR2AHTR2C | |
| SCHEMBL28906371 | 0.76 | HTR2A (0.61) | MAPTPRNPDRD2HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1322646-A1 | 2-(1H-INDOL-3-YL)-2-OXO-ACETIC ACID AMIDES WITH ANTITUMOR ACTIVITY | Novuspharma S.p.A. (IT) | 2003-07-02 | — | — | EP | disclosed |
| WO-2002008225-A1 | 2-(1H-INDOL-3-YL)-2-OXO-ACETIC ACID AMIDES WITH ANTITUMOR ACTIVITY | NOVUSPHARMA S.P.A. (IT) | 2002-01-31 | — | — | WO | disclosed |