Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.61 |
| ▸ | HTR2C | P28335 | 2/20 | 0.61 |
| ▸ | DRD2 | P14416 | 1/20 | 0.61 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.57 |
| ▸ | CDK1 | P06493 | 2/20 | 0.57 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.57 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.49 |
| ▸ | GSK3A | P49840 | 1/20 | 0.48 |
| ▸ | GSK3B | P49841 | 1/20 | 0.48 |
| ▸ | PRNP | P04156 | 1/20 | 0.48 |
| ▸ | TUBB4A | P04350 | 3/20 | 0.47 |
| ▸ | TUBB | P07437 | 3/20 | 0.47 |
| ▸ | TUBA3C | P0DPH7 | 3/20 | 0.47 |
| ▸ | TUBA1B | P68363 | 3/20 | 0.47 |
| ▸ | TUBA4A | P68366 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7495375 | 0.93 | HTR2A (0.58) | HTR2AHTR2CDRD2CCNB2CDK1 | |
| SCHEMBL6992348 | 0.88 | TUBB4A (0.57) | HTR2AHTR2CDRD2CCNB2CDK1 | |
| SCHEMBL6990745 | 0.86 | DRD2 (0.52) | HTR2AHTR2CDRD2CCNB2CDK1 | |
| SCHEMBL28906516 | 0.85 | HTR2A (0.62) | HTR2AHTR2CDRD2TUBB4ATUBB | |
| SCHEMBL14074161 | 0.83 | HTR2A (0.63) | HTR2AHTR2CDRD2CCNB2CDK1 | |
| SCHEMBL11495770 | 0.82 | HTR2A (0.65) | HTR2AHTR2CDRD2CCNB2CDK1 | |
| SCHEMBL28906353 | 0.82 | HTR2A (0.61) | HTR2AHTR2CDRD2MAPTKDM4E | |
| SCHEMBL28906377 | 0.82 | PTGS2 (0.49) | HTR2AHTR2CDRD2MAPTPTGS2 | |
| SCHEMBL28906369 | 0.82 | MAPT (0.55) | HTR2AHTR2CDRD2MAPTPTGS2 | |
| SCHEMBL28906438 | 0.81 | TUBB4A (0.67) | MAPTKDM4EPTGS2KMT2APDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115304533-B | Bisindolemethane type alpha-glucosidase inhibitor and preparation method and application thereof | 中国医学科学院药用植物研究所云南分所 | 2024-04-12 | — | — | CN | disclosed |
| CN-117567447-A | Thiophene-containing bis-indolomethane type a-glucosidase inhibitor and preparation method and application thereof | 中国医学科学院药用植物研究所云南分所 | 2024-02-20 | — | — | CN | disclosed |
| CN-115304533-A | Bis-indole methane type alpha-glucosidase inhibitor and preparation method and application thereof | 中国医学科学院药用植物研究所云南分所 | 2022-11-08 | — | — | CN | disclosed |