Sugi Predict

Sugi Predict / Compounds / SCHEMBL698928

SCHEMBL698928

SCHEMBL698928

Cc1cccc([C@H](C)c2nccn2C(=O)OCc2ccc(F)c(F)c2)c1C

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAOA P21397 1/20 0.35
▸ MAOB P27338 1/20 0.35
▸ TP53 P04637 2/20 0.35
▸ PPARA Q07869 1/20 0.35
▸ FFAR1 O14842 4/20 0.34
▸ BCL9 O00512 1/20 0.34
▸ CTNNB1 P35222 1/20 0.34
▸ HTR6 P50406 2/20 0.34
▸ KDM5A P29375 2/20 0.33
▸ KDM5B Q9UGL1 2/20 0.33
▸ LMNA P02545 2/20 0.33
▸ KDM4C Q9H3R0 1/20 0.33
▸ MRGPRX4 Q96LA9 1/20 0.33
▸ KDM4E B2RXH2 1/20 0.33
▸ ALDH1A1 P00352 1/20 0.33
▸ KMT2A Q03164 1/20 0.33
▸ PTGDR2 Q9Y5Y4 1/20 0.32
▸ DRD4 P21917 1/20 0.32
▸ DRD3 P35462 1/20 0.32
▸ TMEM97 Q5BJF2 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL696648 0.91 MAOB (0.34) MAOBTP53FFAR1LMNAMRGPRX4
SCHEMBL697607 0.91 ALKBH1 (0.36) LMNAALDH1A1PTGDR2CACNA1H
SCHEMBL697361 0.89 GRIN2B (0.41) MAOAMAOBFFAR1LMNAKDM4E
SCHEMBL696660 0.89 GRIN2B (0.38) MAOBFFAR1KDM5AKDM5BLMNA
SCHEMBL697860 0.89 FFAR1 (0.35) FFAR1BCL9CTNNB1LMNA
SCHEMBL716668 0.89 KDM5A (0.37) TP53FFAR1KDM5AKDM5BLMNA
SCHEMBL716667 0.89 KDM5A (0.37) TP53FFAR1KDM5AKDM5BLMNA
SCHEMBL697245 0.88 MMP1 (0.35) MAOBTP53FFAR1LMNAKDM4E
SCHEMBL697730 0.87 GRM5 (0.41) MAOAMAOBTP53FFAR1ALDH1A1
SCHEMBL697165 0.87 GRIN2B (0.42) MAOBFFAR1LMNAKDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2423199-A1 Substituted imidazoles and their use as pesticides Pfizer Limited (GB) 2012-02-29 — — EP disclosed
US-7825149-B2 Substituted imidazoles PFIZER LIMITED (GB) 2010-11-02 — — US disclosed
US-20090312326-A1 SUBSTITUTED IMIDAZOLES PFIZER LIMITED (GB) 2009-12-17 — — US disclosed
US-7592362-B2 Substituted imidazoles PFIZER LIMITED (GB) 2009-09-22 — — US disclosed
US-7547718-B2 Substituted imidazoles PFIZER LIMITED (GB) 2009-06-16 — — US disclosed
US-7544706-B2 Substituted imidazoles PFIZER LIMITED (GB) 2009-06-09 — — US disclosed
US-20080125473-A1 SUBSTITUTED IMIDAZOLES PFIZER LIMITED (GB) 2008-05-29 — — US disclosed
US-20080119536-A1 SUBSTITUTED IMIDAZOLES PFIZER LIMITED (GB) 2008-05-22 — — US disclosed
US-20070167506-A1 SUBSTITUTED IMIDAZOLES PFIZER INC. (US) 2007-07-19 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080125473-A1 SUBSTITUTED IMIDAZOLES ABL1, TYR, CYP3A4 MAOA 380/4885MAOB 186/4885TP53 2394/4885
US-20090312326-A1 SUBSTITUTED IMIDAZOLES ABL1, TYR, CYP3A4 MAOA 380/4885MAOB 186/4885TP53 2394/4885
US-20070167506-A1 SUBSTITUTED IMIDAZOLES ABL1, TYR, CYP3A4 MAOA 380/4885MAOB 186/4885TP53 2394/4885
US-20080119536-A1 SUBSTITUTED IMIDAZOLES ABL1, TYR, CYP3A4 MAOA 380/4885MAOB 186/4885TP53 2394/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.