Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | CTSL | P07711 | 1/20 | 0.37 |
| ▸ | CTSB | P07858 | 1/20 | 0.37 |
| ▸ | CTSS | P25774 | 1/20 | 0.37 |
| ▸ | CTSK | P43235 | 1/20 | 0.37 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CCR5 | P51681 | 1/20 | 0.35 |
| ▸ | REN | P00797 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | ACE | P12821 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6697678 | 0.91 | SIGMAR1 (0.43) | SIGMAR1CTSLCTSBCTSSCTSK | |
| SCHEMBL7027500 | 0.81 | SIGMAR1 (0.45) | SIGMAR1CTSLCTSBCTSSCTSK | |
| SCHEMBL6989994 | 0.81 | SIGMAR1 (0.50) | SIGMAR1CHRM2CHRM5CHRM1CHRM3 | |
| SCHEMBL7026989 | 0.80 | SIGMAR1 (0.49) | SIGMAR1CHRM2CHRM5CHRM1CHRM3 | |
| SCHEMBL7166857 | 0.78 | SIGMAR1 (0.42) | SIGMAR1CTSLCTSBCTSSCTSK | |
| SCHEMBL7025882 | 0.78 | SIGMAR1 (0.42) | SIGMAR1CTSLCTSBCTSSCTSK | |
| SCHEMBL7166861 | 0.75 | SIGMAR1 (0.41) | SIGMAR1CTSLCTSBCTSSCTSK | |
| SCHEMBL6702380 | 0.73 | SIGMAR1 (0.43) | SIGMAR1CTSLCTSBCTSSCTSK | |
| SCHEMBL6697877 | 0.72 | SIGMAR1 (0.46) | SIGMAR1CTSLCHRM2CHRM5CHRM1 | |
| SCHEMBL7684372 | 0.72 | SIGMAR1 (0.42) | SIGMAR1CTSLCTSBCTSSCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1358154-A2 | PYRROLIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF NEURAMINIDASES | Abbott Laboratories (US) | 2003-11-05 | — | — | EP | disclosed |
| EP-1315698-A1 | PYRROLIDINES AS INHIBITORS OF NEURAMINIDASES | ABBOTT LABORATORIES (US) | 2003-06-04 | — | — | EP | disclosed |
| WO-2001028996-A2 | PYRROLIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF NEURAMINIDASES | ABBOTT LABORATORIES (US) | 2001-04-26 | — | — | WO | disclosed |
| WO-1999054299-A1 | PYRROLIDINES AS INHIBITORS OF NEURAMINIDASES | ABBOTT LABORATORIES (US) | 1999-10-28 | — | — | WO | disclosed |