Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | CFTR | P13569 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.32 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.32 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.32 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6991902 | 0.86 | CFTR (0.46) | ALDH1A1LMNARAB9ACFTRKDM4E | |
| SCHEMBL8186103 | 0.84 | MAPK14 (0.36) | ALDH1A1LMNASMN1; SMN2RAB9AHSD17B10 | |
| SCHEMBL6990052 | 0.84 | F7 (0.45) | F2F7F3 | |
| SCHEMBL9292772 | 0.63 | ALDH1A1 (0.46) | ALDH1A1LMNASMN1; SMN2RECQLRAB9A | |
| SCHEMBL20267817 | 0.63 | SLC1A3 (0.40) | KMT2ACYP1A2CYP2C9CYP2C19SLC1A3 | |
| SCHEMBL3594973 | 0.62 | KDM4E (0.49) | KDM4EHSD17B10F2F7F3 | |
| SCHEMBL22164377 | 0.61 | ALDH1A1 (0.39) | ALDH1A1LMNAKMT2ACYP1A2CYP2C9 | |
| SCHEMBL7958440 | 0.60 | SLC1A3 (0.40) | ALDH1A1KMT2ACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL4609928 | 0.60 | TSHR (0.48) | ALDH1A1LMNASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL20267778 | 0.60 | SLC1A3 (0.37) | ALDH1A1KMT2ACYP1A2CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1292579-A1 | SUBSTITUTED POLYCYCLIC ARYL AND HETEROARYL PYRAZINONES USEFUL FOR SELECTIVE INHIBITION OF THE COAGULATION CASCADE | Pharmacia Corporation (US) | 2003-03-19 | — | — | EP | disclosed |
| WO-2001087854-A1 | SUBSTITUTED POLYCYCLIC ARYL AND HETEROARYL PYRAZINONES USEFUL FOR SELECTIVE INHIBITION OF THE COAGULATION CASCADE | PHARMACIA CORPORATION (US) | 2001-11-22 | — | — | WO | disclosed |