Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F7 | P08709 | 17/20 | 0.45 |
| ▸ | F3 | P13726 | 17/20 | 0.45 |
| ▸ | F2 | P00734 | 16/20 | 0.45 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.45 |
| ▸ | F10 | P00742 | 1/20 | 0.40 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6989591 | 0.84 | ALDH1A1 (0.34) | F7F3F2 | |
| SCHEMBL7453183 | 0.77 | F7 (0.51) | F7F3F2PRSS1F10 | |
| SCHEMBL6991902 | 0.72 | CFTR (0.46) | F7F3F2 | |
| SCHEMBL5848054 | 0.72 | F7 (0.67) | F7F3F2PRSS1F10 | |
| SCHEMBL8186103 | 0.70 | MAPK14 (0.36) | — | |
| SCHEMBL3247707 | 0.66 | F2 (0.60) | F7F3F2PRSS1 | |
| SCHEMBL3242830 | 0.64 | F2 (0.66) | F7F3F2PRSS1 | |
| SCHEMBL5885589 | 0.64 | F2 (0.59) | F7F3F2PRSS1 | |
| SCHEMBL6992707 | 0.63 | F7 (0.50) | F7F3F2PRSS1APP | |
| SCHEMBL7878603 | 0.63 | F2 (0.48) | F7F3F2PRSS1APP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1292579-A1 | SUBSTITUTED POLYCYCLIC ARYL AND HETEROARYL PYRAZINONES USEFUL FOR SELECTIVE INHIBITION OF THE COAGULATION CASCADE | Pharmacia Corporation (US) | 2003-03-19 | — | — | EP | disclosed |
| WO-2001087854-A1 | SUBSTITUTED POLYCYCLIC ARYL AND HETEROARYL PYRAZINONES USEFUL FOR SELECTIVE INHIBITION OF THE COAGULATION CASCADE | PHARMACIA CORPORATION (US) | 2001-11-22 | — | — | WO | disclosed |