Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | GRM5 | P41594 | 3/20 | 0.47 |
| ▸ | DRD4 | P21917 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | ME2 | P23368 | 1/20 | 0.39 |
| ▸ | ME1 | P48163 | 1/20 | 0.39 |
| ▸ | ME3 | Q16798 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4713865 | 0.91 | GRM5 (0.52) | TSHRGRM5LMNASMN1; SMN2TP53 | |
| SCHEMBL9261218 | 0.84 | ADRA2A (0.40) | TSHRDRD4LMNADRD2GFER | |
| SCHEMBL4467700 | 0.81 | TSHR (0.44) | TSHRGRM5DRD4LMNASMN1; SMN2 | |
| SCHEMBL4610277 | 0.80 | HCAR2 (0.42) | GRM5LMNASMN1; SMN2DRD2TP53 | |
| SCHEMBL1902514 | 0.79 | GRM5 (0.55) | GRM5LMNASMN1; SMN2MAPK1HTR1A | |
| SCHEMBL7552919 | 0.79 | MAPT (0.41) | TSHRLMNASMN1; SMN2ALDH1A1HTT | |
| SCHEMBL4610798 | 0.78 | GRM5 (0.54) | GRM5DRD4DRD2MAPTME2 | |
| SCHEMBL4609268 | 0.78 | MAPK1 (0.42) | MAPK1 | |
| SCHEMBL4609669 | 0.78 | GRM5 (0.56) | GRM5MAPK1TP53MEN1KMT2A | |
| SCHEMBL27736439 | 0.78 | TSHR (0.59) | TSHRGRM5DRD4LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1979320-A2 | PIPERAZINES AND PIPERIDINES AS mGluR5 POTENTIATORS | AstraZeneca AB (SE) | 2008-10-15 | — | — | EP | disclosed |
| WO-2007087135-A2 | PIPERAZINES AND PIPERIDINES AS mGluR5 POTENTIATORS | ASTRAZENECA AB (SE) | 2007-08-02 | — | — | WO | disclosed |