Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 5/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | GNAI3 | P08754 | 2/20 | 0.46 |
| ▸ | GNAO1 | P09471 | 2/20 | 0.46 |
| ▸ | GNAI1 | P63096 | 2/20 | 0.46 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15294792 | 0.87 | EGLN1 (0.47) | EGLN1HPGDTSHRGAAALDH1A1 | |
| SCHEMBL20827027 | 0.84 | SMN1; SMN2 (0.54) | HPGDTSHRGAAALDH1A1KDM4E | |
| SCHEMBL24485231 | 0.84 | MAPT (0.48) | EPHX1EGLN1HPGDTSHRGAA | |
| SCHEMBL11412912 | 0.82 | SMN1; SMN2 (0.57) | EPHX1HPGDTSHRGAAALDH1A1 | |
| SCHEMBL9865762 | 0.82 | SMN1; SMN2 (0.57) | EPHX1HPGDTSHRGAAALDH1A1 | |
| SCHEMBL883979 | 0.82 | EPHX1 (0.53) | EPHX1POLBGNAI3GNAO1GNAI1 | |
| SCHEMBL22962006 | 0.82 | EPHX1 (0.57) | EPHX1POLBGNAI3GNAO1GNAI1 | |
| Hydrochloric Acid SCHEMBL10337608 | 0.81 | EPHX1 (0.52) | EPHX1POLBGNAI3GNAO1GNAI1 | |
| SCHEMBL23207493 | 0.79 | EPHX2 (0.41) | EGLN1HPGDTSHRGAAALDH1A1 | |
| SCHEMBL6237922 | 0.78 | GNAI3 (0.53) | EPHX1POLBGNAI3GNAO1GNAI1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1322635-A1 | FARNESYL TRANSFERASE INHIBITING QUINOLINE AND QUINAZOLINE DERIVATIVES AS FARNESYL TRANSFERASE INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-07-02 | — | — | EP | claimed |
| WO-2002024682-A1 | FARNESYL TRANSFERASE INHIBITING QUINOLINE AND QUINAZOLINE DERIVATIVES AS FARNESYL TRANSFERASE INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2002-03-28 | — | — | WO | claimed |
| US-20250092091-A1 | KAPPA OPIOID RECEPTOR PEPTIDE AMIDE LIGANDS | Humanwell Pharmaceutical US | 2025-03-20 | — | — | US | disclosed |
| US-12215173-B2 | Kappa opioid receptor peptide amide ligands | HUMANWELL PHARMACEUTICAL US, Inc. (US) | 2025-02-04 | — | — | US | disclosed |
| CN-114615976-A | Kappa opioid receptor peptide amide agonists | 人福医药美国公司 | 2022-06-10 | — | — | CN | disclosed |
| WO-2021026492-A1 | KAPPA OPIOID RECEPTOR PEPTIDE AMIDE AGONISTS | Humanwell Pharmaceutical US (US) | 2021-02-11 | — | — | WO | disclosed |
| US-20210040150-A1 | KAPPA OPIOID RECEPTOR PEPTIDE AMIDE AGONISTS | YICHANG HUMANWELL PHARMACEUTICALS CO., LTD. (CN) | 2021-02-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250092091-A1 | KAPPA OPIOID RECEPTOR PEPTIDE AMIDE LIGANDS | OPRK1, OPRL1, OPRD1 | EPHX1 2721/4885POLB 2311/4885GNAI3 859/4885 |
| US-12215173-B2 | Kappa opioid receptor peptide amide ligands | OPRK1, OPRL1, OPRD1 | EPHX1 2721/4885POLB 2311/4885GNAI3 859/4885 |
| US-20210040150-A1 | KAPPA OPIOID RECEPTOR PEPTIDE AMIDE AGONISTS | OPRK1, OPRL1, OPRD1 | EPHX1 2437/4885POLB 1990/4885GNAI3 863/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.