Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.64 |
| ▸ | POLB | P06746 | 2/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.64 |
| ▸ | GAA | P10253 | 1/20 | 0.63 |
| ▸ | MEN1 | O00255 | 4/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.63 |
| ▸ | HPGD | P15428 | 1/20 | 0.61 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.61 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.61 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7448471 | 0.84 | ALDH1A1 (0.67) | ALDH1A1POLBL3MBTL1GAAMEN1 | |
| SCHEMBL7448478 | 0.84 | ALDH1A1 (0.67) | ALDH1A1POLBL3MBTL1GAAMEN1 | |
| SCHEMBL11619526 | 0.82 | ALDH1A1 (0.72) | ALDH1A1POLBL3MBTL1GAAMEN1 | |
| SCHEMBL6988577 | 0.82 | ALDH1A1 (0.61) | ALDH1A1POLBL3MBTL1GAAMEN1 | |
| SCHEMBL6999720 | 0.81 | ALDH1A1 (0.60) | ALDH1A1POLBL3MBTL1GAAMEN1 | |
| SCHEMBL394112 | 0.81 | MEN1 (0.62) | ALDH1A1POLBL3MBTL1GAAMEN1 | |
| SCHEMBL394111 | 0.81 | MEN1 (0.62) | ALDH1A1POLBL3MBTL1GAAMEN1 | |
| SCHEMBL24705100 | 0.80 | HSD11B1 (0.45) | ALDH1A1POLBL3MBTL1GAAMEN1 | |
| SCHEMBL17049356 | 0.80 | ALDH1A1 (0.66) | ALDH1A1POLBL3MBTL1GAAMEN1 | |
| SCHEMBL17049355 | 0.80 | ALDH1A1 (0.66) | ALDH1A1POLBL3MBTL1GAAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0641343-B1 | 4-MERCAPTOACETYLAMINO-[2] BENZAZEPINONE(3) DERIVATIVES, AND USE AS ENKEPHALINASE INHIBITORS | MERRELL PHARMA INC (US) | 2003-06-25 | — | — | EP | disclosed |
| EP-0641343-A1 | 4-MERCAPTOACETYLAMINO- 2] BENZAZEPINONE(3) DERIVATIVES, AND USE AS ENKEPHALINASE INHIBITORS | MERRELL PHARMACEUTICALS INC. (US) | 1995-03-08 | — | — | EP | disclosed |
| WO-1993023397-A1 | 4-MERCAPTOACETYLAMINO-[2] BENZAZEPINONE(3) DERIVATIVES, AND USE AS ENKEPHALINASE INHIBITORS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-11-25 | — | — | WO | disclosed |
| US-5238932-A | Mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-08-24 | — | — | US | disclosed |