Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 3/20 | 0.60 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.60 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.60 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.60 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.60 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.60 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.60 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.60 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.60 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | OPRM1 | P35372 | 17/20 | 0.48 |
| ▸ | OPRK1 | P41145 | 17/20 | 0.48 |
| ▸ | OPRD1 | P41143 | 16/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.44 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6811518 | 0.88 | HDAC1 (0.59) | HDAC1HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL6810892 | 0.83 | HDAC1 (0.48) | HDAC1HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL6811536 | 0.82 | HDAC1 (0.61) | HDAC1HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL6825502 | 0.80 | CHRM2 (0.47) | HDAC1HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL12718708 | 0.77 | HDAC1 (0.53) | HDAC1HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL5970924 | 0.77 | HDAC1 (0.50) | HDAC1HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL16558088 | 0.77 | HDAC1 (0.75) | HDAC1HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL6816345 | 0.77 | ALDH1A1 (0.47) | HDAC1HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL6810897 | 0.76 | ATAD2 (0.45) | HDAC1HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL16061662 | 0.76 | ALDH1A1 (0.55) | HDAC1HDAC8HDAC6HDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1345930-A2 | PHARMACEUTICAL COMPOUNDS | ELI LILLY AND COMPANY (US) | 2003-09-24 | — | — | EP | disclosed |
| WO-2002050067-A2 | PHARMACEUTICAL HETEROCYCLIC COMPOUNDS | ELI LILLY AND COMPANY (US) | 2002-06-27 | — | — | WO | disclosed |