Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD | Q03181 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11154240 | 0.81 | PPARD (0.44) | PPARDTSHRTP53TDP1ACHE | |
| SCHEMBL12207660 | 0.81 | TSHR (0.43) | PPARDTSHRTP53TDP1ACHE | |
| SCHEMBL11762919 | 0.80 | PPARD (0.45) | PPARDTSHRTP53TDP1ACHE | |
| SCHEMBL7889487 | 0.79 | CYP3A4 (0.48) | TSHRGAA | |
| SCHEMBL6985563 | 0.77 | TSHR (0.40) | PPARDTSHRTP53TDP1ACHE | |
| SCHEMBL7900868 | 0.77 | LPAR3 (0.53) | TSHRMAPTMEN1KMT2A | |
| SCHEMBL3289373 | 0.75 | TSHR (0.48) | PPARDTSHRTP53TDP1ACHE | |
| SCHEMBL6988924 | 0.74 | TSHR (0.37) | TSHRTP53TDP1ACHEMEN1 | |
| SCHEMBL6990204 | 0.72 | ACHE (0.42) | TSHRTP53TDP1ACHEMEN1 | |
| SCHEMBL11155261 | 0.71 | PPARD (0.40) | PPARDTSHRTP53TDP1ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0739345-B1 | CYCLIC POLYAMINES | ANORMED INC (CA) | 2003-04-09 | — | — | EP | disclosed |
| US-5698546-A | Cyclic polyamines | JOHNSON MATTHEY PUBLIC LIMTED COMPANY (GB) | 1997-12-16 | — | — | US | disclosed |
| EP-0739345-A1 | CYCLIC POLYAMINES | JOHNSON MATTHEY PUBLIC LIMITED COMPANY (GB) | 1996-10-30 | — | — | EP | disclosed |
| WO-1995018808-A1 | CYCLIC POLYAMINES | JOHNSON MATTHEY PUBLIC LIMITED COMPANY (GB) | 1995-07-13 | — | — | WO | disclosed |