Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | GABBR2 | O75899 | 3/20 | 0.33 |
| ▸ | GABBR1 | Q9UBS5 | 3/20 | 0.33 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
| ▸ | THPO | P40225 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6985563 | 0.87 | TSHR (0.40) | TSHRMEN1KMT2ATP53TDP1 | |
| SCHEMBL24268058 | 0.78 | GABBR2 (0.33) | TSHRCYP1A2GABBR2GABBR1GABRR1 | |
| SCHEMBL12207660 | 0.78 | TSHR (0.43) | TSHRMEN1KMT2ATP53TDP1 | |
| SCHEMBL21049917 | 0.75 | TSHR (0.37) | TSHRMEN1KMT2ATP53TDP1 | |
| SCHEMBL3103434 | 0.75 | ACHE (0.40) | TSHRMEN1KMT2ATP53TDP1 | |
| SCHEMBL6990161 | 0.74 | PPARD (0.46) | TSHRMEN1KMT2ATP53TDP1 | |
| SCHEMBL3289373 | 0.72 | TSHR (0.48) | TSHRMEN1KMT2ATP53TDP1 | |
| SCHEMBL8637994 | 0.69 | TSHR (0.32) | TSHRTP53TDP1 | |
| SCHEMBL6990204 | 0.69 | ACHE (0.42) | TSHRMEN1KMT2ATP53TDP1 | |
| SCHEMBL11154240 | 0.69 | PPARD (0.44) | TSHRTP53TDP1ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0739345-B1 | CYCLIC POLYAMINES | ANORMED INC (CA) | 2003-04-09 | — | — | EP | disclosed |
| US-5698546-A | Cyclic polyamines | JOHNSON MATTHEY PUBLIC LIMTED COMPANY (GB) | 1997-12-16 | — | — | US | disclosed |
| EP-0739345-A1 | CYCLIC POLYAMINES | JOHNSON MATTHEY PUBLIC LIMITED COMPANY (GB) | 1996-10-30 | — | — | EP | disclosed |
| WO-1995018808-A1 | CYCLIC POLYAMINES | JOHNSON MATTHEY PUBLIC LIMITED COMPANY (GB) | 1995-07-13 | — | — | WO | disclosed |