Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.31 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3140453 | 0.73 | HPGD (0.43) | LMNA | |
| SCHEMBL3140771 | 0.64 | NPC1 (0.40) | LMNA | |
| SCHEMBL3140703 | 0.64 | PARP1 (0.43) | — | |
| SCHEMBL12023001 | 0.63 | MAPK8 (0.46) | KDM4ELMNA | |
| SCHEMBL3140842 | 0.63 | ALDH1A1 (0.35) | P2RX7NR3C1 | |
| SCHEMBL4086572 | 0.63 | NPC1 (0.50) | KDM4ELMNA | |
| SCHEMBL4080928 | 0.63 | P2RX7 (0.40) | P2RX7 | |
| SCHEMBL4245581 | 0.62 | CTSL (0.39) | — | |
| SCHEMBL4096182 | 0.62 | HTR2A (0.40) | — | |
| SCHEMBL6755715 | 0.62 | MAPK8 (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1358176-A2 | INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | Amura Therapeutics Limited (GB) | 2003-11-05 | — | — | EP | disclosed |
| WO-2002057246-A2 | INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | AMURA THERAPEUTICS LIMITED (GB) | 2002-07-25 | — | — | WO | disclosed |