Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY5R | Q15761 | 5/20 | 0.40 |
| ▸ | HTR4 | Q13639 | 6/20 | 0.33 |
| ▸ | REN | P00797 | 2/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.32 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.31 |
| ▸ | HTR3B | O95264 | 1/20 | 0.31 |
| ▸ | HTR3A | P46098 | 1/20 | 0.31 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.31 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.31 |
| ▸ | SSTR4 | P31391 | 2/20 | 0.31 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.31 |
| ▸ | SSTR2 | P30874 | 1/20 | 0.31 |
| ▸ | SSTR3 | P32745 | 1/20 | 0.31 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.31 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6983375 | 0.88 | NPY5R (0.44) | NPY5RHTR4RENSLC6A2SLC6A4 | |
| SCHEMBL6987001 | 0.86 | NPY5R (0.42) | NPY5RHTR4RENSLC6A2SLC6A4 | |
| SCHEMBL27604172 | 0.82 | NPY5R (0.45) | NPY5RHTR4HTR3EHTR3BHTR3A | |
| SCHEMBL6990117 | 0.81 | NPY5R (0.44) | NPY5RHTR4HTR3EHTR3BHTR3A | |
| SCHEMBL6986965 | 0.78 | NPY5R (0.42) | NPY5RHTR4HTR3EHTR3BHTR3A | |
| SCHEMBL6829077 | 0.71 | NPY5R (0.61) | NPY5RHTR4 | |
| SCHEMBL6823480 | 0.67 | NPY5R (0.56) | NPY5R | |
| SCHEMBL9439154 | 0.66 | HTT (0.39) | SLC6A2SLC6A4SLC6A3SSTR4SSTR1 | |
| SCHEMBL6829107 | 0.64 | NPY5R (0.64) | NPY5REZH2 | |
| SCHEMBL6826776 | 0.64 | NPY5R (0.49) | NPY5R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1358157-A1 | CARBAZOLE DERIVATIVES AND THEIR USE AS NEUROPEPTIDE Y5 RECEPTOR LIGANDS | AstraZeneca AB (SE) | 2003-11-05 | — | — | EP | disclosed |
| WO-2002051806-A1 | CARBAZOLE DERIVATIVES AND THEIR USE AS NEUROPEPTIDE Y5 RECEPTOR LIGANDS | ASTRAZENECA AB (SE) | 2002-07-04 | — | — | WO | disclosed |