Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.76 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.76 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.68 |
| ▸ | POLB | P06746 | 1/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.68 |
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | CASP3 | P42574 | 1/20 | 0.57 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.57 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.57 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5928599 | 0.86 | ALDH1A1 (1.00) | ALDH1A1HSD17B10KDM4EPOLBSMN1; SMN2 | |
| SCHEMBL6990712 | 0.84 | KDM4E (0.72) | ALDH1A1HSD17B10KDM4EPOLBHCAR2 | |
| SCHEMBL9361352 | 0.81 | KDM4E (1.00) | ALDH1A1HSD17B10KDM4EPOLBSMN1; SMN2 | |
| SCHEMBL28756536 | 0.81 | SMN1; SMN2 (1.00) | ALDH1A1HSD17B10SMN1; SMN2LMNAMAPT | |
| SCHEMBL10634666 | 0.81 | KDM4E (0.68) | ALDH1A1HSD17B10KDM4EPOLBSMN1; SMN2 | |
| SCHEMBL252897 | 0.80 | KMT2A (0.73) | ALDH1A1KDM4EPOLBSMN1; SMN2HCAR2 | |
| SCHEMBL29437944 | 0.80 | KMT2A (0.73) | ALDH1A1KDM4EPOLBSMN1; SMN2HCAR2 | |
| SCHEMBL9365066 | 0.80 | KDM4E (0.67) | ALDH1A1HSD17B10KDM4EPOLBSMN1; SMN2 | |
| SCHEMBL10501327 | 0.79 | KMT2A (0.83) | ALDH1A1KDM4EPOLBSMN1; SMN2HCAR2 | |
| SCHEMBL10694565 | 0.79 | SMN1; SMN2 (0.69) | ALDH1A1HSD17B10POLBSMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0980374-B1 | PHOSPHODIESTERASE 4-INHIBITING DIAZEPINOINDOLONES | PFIZER HOLDING FRANCE (FR) | 2003-02-12 | — | — | EP | disclosed |
| US-6239130-B1 | ASTHMA, ATOPIC DERMATITIS, RHEUMATOID ARTHRITIS, INFLAMMATORY BOWEL DISORDERS, PULMONARY HYPERTENSION, LIVER INJURY, BONE LOSS, SEPTIC SHOCK, OR MULTIPLE SCLEROSIS, | WARNER-LAMBERT COMPANY | 2001-05-29 | — | — | US | disclosed |
| EP-0980374-A1 | PHOSPHODIESTERASE 4-INHIBITING DIAZEPINOINDOLONES | PARKE-DAVIS (FR) | 2000-02-23 | — | — | EP | disclosed |
| WO-1998049169-A1 | PHOSPHODIESTERASE 4-INHIBITING DIAZEPINOINDOLONES | PARKE-DAVIS (FR) | 1998-11-05 | — | — | WO | disclosed |