Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.55 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.55 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.55 |
| ▸ | PLIN1 | O60240 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | RECQL | P46063 | 2/20 | 0.55 |
| ▸ | PLIN5 | Q00G26 | 2/20 | 0.55 |
| ▸ | ABHD5 | Q8WTS1 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | F3 | P13726 | 2/20 | 0.55 |
| ▸ | TNKS | O95271 | 1/20 | 0.55 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.55 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.55 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.55 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.55 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6990829 | 1.00 | MAPT (0.55) | MAPTHDAC3HDAC4HDAC1HDAC2 | |
| SCHEMBL13159756 | 0.83 | MAPT (0.53) | MAPTHDAC3HDAC4HDAC1HDAC2 | |
| SCHEMBL28735626 | 0.83 | MAPT (0.53) | MAPTHDAC3HDAC4HDAC1HDAC2 | |
| SCHEMBL4029202 | 0.79 | MAPT (0.64) | MAPTHDAC3HDAC4HDAC1HDAC2 | |
| SCHEMBL4023735 | 0.79 | MAPT (0.64) | MAPTHDAC3HDAC4HDAC1HDAC2 | |
| SCHEMBL8849603 | 0.78 | MAPT (0.47) | MAPTHDAC3HDAC4HDAC1HDAC2 | |
| SCHEMBL16588259 | 0.78 | HDAC1 (0.61) | MAPTHDAC3HDAC4HDAC1HDAC2 | |
| SCHEMBL11691730 | 0.76 | MAOB (0.54) | MAPTLMNAALDH1A1SMN1; SMN2CYP1B1 | |
| SCHEMBL11691732 | 0.76 | MAOB (0.54) | MAPTLMNAALDH1A1SMN1; SMN2CYP1B1 | |
| SCHEMBL11476908 | 0.76 | TDP1 (0.61) | MAPTHDAC3HDAC4HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-60245637-A | — | — | None | — | — | JP | disclosed |
| CN-111153898-B | Thiourea derivative and preparation method and application thereof | 南华大学 | 2022-11-11 | — | — | CN | disclosed |
| CN-111153898-A | Thiourea derivative and preparation method and application thereof | 南华大学 | 2020-05-15 | — | — | CN | disclosed |
| US-9334236-B2 | Lactam-based compounds with a urethane or urea functional group, and uses thereof | ISP INVESTMENTS INC. (US) | 2016-05-10 | — | — | US | disclosed |
| US-9334236-B2 | Lactam-based compounds with a urethane or urea functional group, and uses thereof | ISP INVESTMENTS INC. (US) | 2016-05-10 | — | — | US | disclosed |
| US-20120149861-A1 | LACTAM-BASED COMPOUNDS WITH A URETHANE OR UREA FUNCTIONAL GROUP, AND USES THEREOF | ISP INVESTMENTS LLC | 2012-06-14 | — | — | US | disclosed |
| US-20120149861-A1 | LACTAM-BASED COMPOUNDS WITH A URETHANE OR UREA FUNCTIONAL GROUP, AND USES THEREOF | ISP INVESTMENTS LLC | 2012-06-14 | — | — | US | disclosed |
| WO-2011022457-A1 | LACTAM-BASED COMPOUNDS WITH A URETHANE OR UREA FUNCTIONAL GROUP, AND USES THEREOF | ISP INVESTMENTS INC. (US) | 2011-02-24 | — | — | WO | disclosed |
| EP-0874809-B1 | CARBAMOYLOXY DERIVATIVES OF MUTILINE AND THEIR USE AS ANTIBACTERIALS | SMITHKLINE BEECHAM PLC (GB) | 2003-08-27 | — | — | EP | disclosed |
| US-6239175-B1 | Carbamoyloxy derivatives of mutiline and their use as antibacterials | SMITHKLINE BEECHAM P.L.C. (GB) | 2001-05-29 | — | — | US | disclosed |
| US-6020368-A | MICROBIOCIDES | HINKS JEREMY DAVID (US) | 2000-02-01 | — | — | US | disclosed |
| CN-1214039-A | Carbamoyloxy derivatives of mutiline and their use as antibacterials | SMITHKLINE BEECHAM PLC (GB) | 1999-04-14 | — | — | CN | disclosed |
| EP-0874809-A1 | CARBAMOYLOXY DERIVATIVES OF MUTILINE AND THEIR USE AS ANTIBACTERIALS | SMITHKLINE BEECHAM PLC (GB) | 1998-11-04 | — | — | EP | disclosed |
| WO-1997025309-A1 | CARBAMOYLOXY DERIVATIVES OF MUTILINE AND THEIR USE AS ANTIBACTERIALS | SMITHKLINE BEECHAM PLC (GB) | 1997-07-17 | — | — | WO | disclosed |
| US-5386057-A | Process for the preparation of acyl isocyanates | SOCIETE NATIONALE DES POUDRES ET EXPLOSIFS (FR) | 1995-01-31 | — | — | US | disclosed |
| JP-S60245637-A | PHOTOSENSITIVE, HEAT-RESISTANT MATERIAL | MITSUBISHI ELECTRIC CORP | 1985-12-05 | — | — | JP | disclosed |
| US-4061630-A | 7-Substituted-ureido-3-carbamoyloxymethyl cephalosporin antibiotics | ELI LILLY AND COMPANY (US) | 1977-12-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120149861-A1 | LACTAM-BASED COMPOUNDS WITH A URETHANE OR UREA FUNCTIONAL GROUP, AND USES THEREOF | CUTA, PUF60, PAM | MAPT 2470/4885HDAC3 2695/4885HDAC4 2195/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.