Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 6/20 | 0.63 |
| ▸ | BCHE | P06276 | 5/20 | 0.63 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.40 |
| ▸ | CRBN | Q96SW2 | 3/20 | 0.39 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6989427 | 0.81 | ACHE (0.62) | ACHEBCHEFAAHGPR119CRBN | |
| SCHEMBL4113644 | 0.78 | GPR119 (0.42) | ACHEFAAHGPR119KDM4EPKM | |
| SCHEMBL13597348 | 0.78 | GPR119 (0.42) | ACHEFAAHGPR119KDM4EPKM | |
| SCHEMBL222186 | 0.78 | ACHE (1.00) | ACHEBCHE | |
| SCHEMBL13596431 | 0.77 | GPR119 (0.40) | ACHEBCHEFAAHGPR119KDM4E | |
| SCHEMBL13597347 | 0.77 | GPR119 (0.43) | FAAHGPR119KDM4EPKM | |
| SCHEMBL4128212 | 0.76 | GPR119 (0.42) | ACHEFAAHGPR119KDM4EPKM | |
| SCHEMBL4120800 | 0.76 | GPR119 (0.42) | ACHEFAAHGPR119KDM4EPKM | |
| SCHEMBL4120804 | 0.76 | GPR119 (0.42) | ACHEFAAHGPR119KDM4EPKM | |
| SCHEMBL4120922 | 0.75 | GPR119 (0.42) | ACHEFAAHGPR119KDM4EPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0646115-B1 | HETEROCYCLIC-CYCLIC AMINE DERIVATIVES | EISAI CO LTD (JP) | 2003-01-22 | — | — | EP | disclosed |
| US-6498255-B2 | CHOLINESTERASE INHIBITORS; COGNITION ACTIVATORS; ALZHEIMER'S DISEASE; E.G., 3-(2-(1-(PHENYLMETHYL)-4-PIPERIDINYL)ETHYL)-1,2-BENZISOXAZOLE | PFIZER INC. | 2002-12-24 | — | — | US | disclosed |
| US-6326382-B1 | CHOLINESTERASE INHIBITORS; USEFUL IN ENHANCING MEMORY IN PATIENTS SUFFERING FROM DEMENTIA AND ALZHEIMER'S DISEASE | EISAI CO., LTD (JP) | 2001-12-04 | — | — | US | disclosed |
| US-5538984-A | Methods of using piperidyl-benzisoxazole and benisothiazole derivatives as cholinesterase inhibitors | PFIZER INC. (US) | 1996-07-23 | — | — | US | disclosed |
| EP-0646115-A1 | HETEROCYCLIC-CYCLIC AMINE DERIVATIVES | Eisai Co., Ltd. (JP) | 1995-04-05 | — | — | EP | disclosed |
| WO-1992017475-A1 | HETEROCYCLIC-CYCLIC AMINE DERIVATIVES | PFIZER INC. (US) | 1992-10-15 | — | — | WO | disclosed |