Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 11/20 | 0.62 |
| ▸ | BCHE | P06276 | 8/20 | 0.62 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.43 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | GRIA1 | P42261 | 2/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6848280 | 0.91 | ACHE (0.64) | ACHEBCHE | |
| SCHEMBL6986573 | 0.88 | ACHE (0.72) | ACHEBCHE | |
| SCHEMBL6989899 | 0.84 | ACHE (0.72) | ACHEBCHE | |
| SCHEMBL7672658 | 0.83 | ACHE (0.65) | ACHEBCHE | |
| SCHEMBL7674312 | 0.81 | ACHE (0.71) | ACHEBCHE | |
| SCHEMBL6991285 | 0.81 | ACHE (0.63) | ACHEBCHECRBNFAAHGPR119 | |
| Icopezil SCHEMBL194482 | 0.77 | ACHE (1.00) | ACHEBCHE | |
| Icopezil SCHEMBL2231222 | 0.76 | ACHE (1.00) | ACHEBCHE | |
| SCHEMBL4126446 | 0.75 | ACHE (0.43) | ACHEBCHEFAAHGPR119 | |
| SCHEMBL13596543 | 0.73 | ACHE (0.42) | ACHEBCHEFAAHGPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0646115-B1 | HETEROCYCLIC-CYCLIC AMINE DERIVATIVES | EISAI CO LTD (JP) | 2003-01-22 | — | — | EP | disclosed |
| EP-1048302-A2 | Radiotracers for in vivo study of acetylcholinesterase and Alzheimer's disease | Pfizer Products Inc. (US) | 2000-11-02 | — | — | EP | disclosed |