Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 3/20 | 0.51 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.46 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.37 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15387053 | 0.82 | MAPK8 (0.53) | MAPK10MAPK8PKMBCAT2PTPN2 | |
| SCHEMBL7002263 | 0.81 | MAPK8 (0.49) | MAPK10MAPK8PKMBCAT2PTPN2 | |
| SCHEMBL1317724 | 0.80 | PKM (0.53) | MAPK10MAPK8PKMBCAT2PTPN2 | |
| SCHEMBL2593851 | 0.80 | MAPK8 (0.64) | MAPK10MAPK8PKMBCAT2PTPN2 | |
| SCHEMBL21468232 | 0.79 | MAPK8 (0.48) | MAPK10MAPK8PKMBCAT2PTPN2 | |
| SCHEMBL16011480 | 0.77 | PKM (0.57) | MAPK10MAPK8PKMBCAT2PTPN2 | |
| SCHEMBL25875491 | 0.74 | PKM (0.55) | MAPK10MAPK8PKMPTPN2PTPN1 | |
| SCHEMBL9069534 | 0.72 | L3MBTL1 (0.68) | MAPK10MAPK8BCAT2KMT2AMEN1 | |
| SCHEMBL23997391 | 0.71 | MAPK8 (0.65) | MAPK10MAPK8PKMBCAT2IRAK4 | |
| SCHEMBL20339308 | 0.71 | MAPK8 (0.65) | MAPK10MAPK8PKMPTPN2PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1341773-A2 | SUBSTITUTED 1,3,5-TRIAZINES AND PYRIMIDINES AS ABCA-1 ELEVATING COMPOUNDS AGAINST CORONARY ARTERY DISEASE OR ATHEROSCLEROSIS | CV THERAPEUTICS, INC. (US) | 2003-09-10 | — | — | EP | disclosed |
| WO-2002046172-A2 | SUBSTITUTED 1, 3, 5-TRIAZINES AND PYRIMIDINES AS ABCA-1 ELEVATING COMPOUNDS AGAINST CORONARY ARTERY DISEASE OR ATHEROSCLEROSIS | CV THERAPEUTICS, INC. (US) | 2002-06-13 | — | — | WO | disclosed |