Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RELA | Q04206 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | APEX1 | P27695 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.47 |
| ▸ | IP6K1 | Q92551 | 3/20 | 0.42 |
| ▸ | IP6K3 | Q96PC2 | 1/20 | 0.42 |
| ▸ | IP6K2 | Q9UHH9 | 1/20 | 0.42 |
| ▸ | PLG | P00747 | 1/20 | 0.42 |
| ▸ | PLAU | P00749 | 1/20 | 0.42 |
| ▸ | PLAT | P00750 | 1/20 | 0.42 |
| ▸ | KLK1 | P06870 | 1/20 | 0.42 |
| ▸ | GRM4 | Q14833 | 3/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | S100A4 | P26447 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6991395 | 1.00 | RELA (0.49) | RELAMAPTLMNACYP3A4APEX1 | |
| SCHEMBL6992568 | 0.80 | MAPT (0.44) | MAPTLMNACYP3A4APEX1MAPK1 | |
| SCHEMBL27549858 | 0.76 | MAPT (0.43) | MAPTLMNACYP3A4APEX1MAPK1 | |
| SCHEMBL6991069 | 0.75 | PLAU (0.55) | MAPTLMNACYP3A4APEX1MAPK1 | |
| SCHEMBL27527771 | 0.72 | PARG (0.53) | MAPTLMNACYP3A4APEX1MAPK1 | |
| SCHEMBL29786977 | 0.71 | LMNA (0.50) | MAPTLMNACYP3A4APEX1MAPK1 | |
| SCHEMBL1317870 | 0.71 | LMNA (0.50) | MAPTLMNACYP3A4APEX1MAPK1 | |
| SCHEMBL29536823 | 0.70 | MAPT (0.70) | MAPTLMNACYP3A4APEX1MAPK1 | |
| SCHEMBL144590 | 0.70 | MAPT (0.70) | MAPTLMNACYP3A4APEX1MAPK1 | |
| SCHEMBL11209385 | 0.70 | RELA (0.91) | RELAMAPTPLGPLAUPLAT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1023268-B1 | ISOQUINOLINES AS UROKINASE INHIBITORS | PFIZER LTD (GB) | 2003-05-21 | — | — | EP | disclosed |
| US-6248738-B1 | ANTIULCER AGENTS, ANGIOGENESIS INHIBITORS, ANTIMETASTASIS AGENTS, ANTITUMOR AGENTS | PFIZER INC. | 2001-06-19 | — | — | US | disclosed |