SCHEMBL6991708

SCHEMBL6991708

Nc1cccc(Cc2[c]cccc2)c1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 3/20 0.48
MAOA P21397 3/20 0.48
CYP19A1 P11511 2/20 0.43
CA1 P00915 1/20 0.40
CA2 P00918 1/20 0.40
CA9 Q16790 1/20 0.40
SIGMAR1 Q99720 2/20 0.39
CYP3A4 P08684 2/20 0.38
CASP1 P29466 1/20 0.38
RECQL P46063 1/20 0.38
CYP11B1 P15538 2/20 0.35
CYP11B2 P19099 2/20 0.35
PARP1 P09874 1/20 0.35
MAPT P10636 2/20 0.34
LMNA P02545 1/20 0.33
HTT P42858 1/20 0.33
RAB9A P51151 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
PRMT1 Q99873 1/20 0.33
CYP17A1 P05093 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17956849 0.79 CYP3A4 (0.50) MAOBMAOACYP19A1CA1CA2
SCHEMBL8713096 0.79 TSHR (0.40) CYP11B1CYP11B2
SCHEMBL3153832 0.79 PNMT (0.46) SIGMAR1CYP3A4
SCHEMBL3151281 0.79 TAAR1 (0.43) MAOBCYP11B1CYP11B2MAPT
SCHEMBL79754 0.78 CALM1 (0.50) CYP3A4MAPTLMNA
SCHEMBL30583096 0.76 MAOB (0.62) MAOBMAOACYP19A1CA1CA2
SCHEMBL49433 0.76 MAOB (0.62) MAOBMAOACYP19A1CA1CA2
SCHEMBL6978758 0.75 CHRM2 (0.49) MAOBSIGMAR1
SCHEMBL8939739 0.75 KDM4E (0.42) MAOBHTTSMN1; SMN2
SCHEMBL399652 0.74 MAOB (0.68) MAOBMAOACYP19A1CA1CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1292579-A1 SUBSTITUTED POLYCYCLIC ARYL AND HETEROARYL PYRAZINONES USEFUL FOR SELECTIVE INHIBITION OF THE COAGULATION CASCADE Pharmacia Corporation (US) 2003-03-19 EP claimed
WO-2001087854-A1 SUBSTITUTED POLYCYCLIC ARYL AND HETEROARYL PYRAZINONES USEFUL FOR SELECTIVE INHIBITION OF THE COAGULATION CASCADE PHARMACIA CORPORATION (US) 2001-11-22 WO claimed
WO-2001087851-A1 SUBSTITUTED POLYCYCLIC ARYL AND HETEROARYL PYRIMIDINONES USEFUL FOR SELECTIVE INHIBITION OF THE COAGULATION CASCADE PHARMACIA CORPORATION (US) 2001-11-22 WO claimed
EP-1292579-A1 SUBSTITUTED POLYCYCLIC ARYL AND HETEROARYL PYRAZINONES USEFUL FOR SELECTIVE INHIBITION OF THE COAGULATION CASCADE Pharmacia Corporation (US) 2003-03-19 EP disclosed
WO-2001087854-A1 SUBSTITUTED POLYCYCLIC ARYL AND HETEROARYL PYRAZINONES USEFUL FOR SELECTIVE INHIBITION OF THE COAGULATION CASCADE PHARMACIA CORPORATION (US) 2001-11-22 WO disclosed