Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.52 |
| ▸ | HTR2A | P28223 | 3/20 | 0.52 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 2/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.41 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.41 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.39 |
| ▸ | GABBR1 | Q9UBS5 | 1/20 | 0.39 |
| ▸ | PNMT | P11086 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1258400 | 1.00 | TAAR1 (0.52) | TAAR1HTR2ACHRNB2CHRNA4HRH1 | |
| SCHEMBL7291506 | 1.00 | TAAR1 (0.52) | TAAR1HTR2ACHRNB2CHRNA4HRH1 | |
| Iodide SCHEMBL28932197 | 0.98 | TAAR1 (0.50) | TAAR1HTR2ACHRNB2CHRNA4HRH1 | |
| SCHEMBL17906494 | 0.88 | CHRNB2 (0.57) | TAAR1HTR2ACHRNB2CHRNA4 | |
| SCHEMBL8696036 | 0.83 | HRH1 (0.56) | TAAR1HTR2AHRH1SLC6A2SLC6A4 | |
| SCHEMBL11133727 | 0.78 | SLC7A5 (0.54) | TAAR1HTR2AHRH1SLC6A2SLC6A4 | |
| SCHEMBL22012999 | 0.77 | ESR1 (0.38) | TAAR1HTR2AHRH1SLC6A2SLC6A4 | |
| SCHEMBL22349242 | 0.77 | ESR1 (0.42) | TAAR1HTR2A | |
| SCHEMBL5700800 | 0.77 | LMNA (0.46) | TAAR1HTR2AHRH1 | |
| SCHEMBL8322089 | 0.77 | ESR1 (0.38) | TAAR1HTR2AHRH1SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1069132-B1 | Bicyclic derivatives of amino-pyrazinones, process of preparation and pharmaceutical compositions comprising them | SERVIER LAB (FR) | 2003-10-01 | — | — | EP | disclosed |
| US-6277851-B1 | ORALLY ADMINISTERED TRYPSIN-RELATED SERINE PROTEASE INHIBITORS; ANTICOAGULANTS | ADIR ET COMPAGNIE (FR) | 2001-08-21 | — | — | US | disclosed |
| EP-1069132-A1 | Bicyclic derivatives of amino-pyrazinones, process of preparation and pharmaceutical compositions comprising them | ADIR ET COMPAGNIE (FR) | 2001-01-17 | — | — | EP | disclosed |