Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 11/20 | 0.39 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SSTR3 | P32745 | 2/20 | 0.35 |
| ▸ | CTSB | P07858 | 1/20 | 0.35 |
| ▸ | CTSS | P25774 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.35 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.35 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.35 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.35 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.35 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6300424 | 0.92 | IDO1 (0.44) | CTSLIDO1KMT2ACTSBCTSS | |
| SCHEMBL6701575 | 0.90 | TRPV1 (0.44) | CTSLKLKB1CYP2D6CYP2C9 | |
| SCHEMBL6300527 | 0.90 | CTSL (0.38) | CTSLIDO1KMT2ACTSBCTSS | |
| SCHEMBL6300604 | 0.89 | CTSL (0.38) | CTSLIDO1KMT2ACTSBCTSS | |
| SCHEMBL6294295 | 0.88 | CTSL (0.40) | CTSLCYP2D6CYP2C9SSTR3 | |
| SCHEMBL6295728 | 0.88 | CTSL (0.36) | CTSLKLKB1IDO1KMT2ASSTR3 | |
| SCHEMBL6702836 | 0.88 | CTSL (0.41) | CTSLKLKB1CYP2D6CYP2C9CTSB | |
| SCHEMBL6699255 | 0.87 | CTSL (0.40) | CTSLKLKB1CYP2D6CYP2C9SSTR3 | |
| SCHEMBL6695685 | 0.86 | CTSB (0.45) | CTSLKLKB1CYP2D6CYP2C9KMT2A | |
| SCHEMBL6699096 | 0.83 | CTSL (0.45) | CTSLIDO1KMT2ACTSBCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1358176-A2 | INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | Amura Therapeutics Limited (GB) | 2003-11-05 | — | — | EP | disclosed |
| WO-2002057246-A2 | INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | AMURA THERAPEUTICS LIMITED (GB) | 2002-07-25 | — | — | WO | disclosed |