Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSB | P07858 | 2/20 | 0.45 |
| ▸ | CTSL | P07711 | 10/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CCR3 | P51677 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CTSS | P25774 | 2/20 | 0.36 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.35 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | MMP1 | P03956 | 1/20 | 0.34 |
| ▸ | SSTR3 | P32745 | 1/20 | 0.34 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6701120 | 0.91 | CTSB (0.49) | CTSBCTSLCTSSCTSKUTS2R | |
| SCHEMBL6702836 | 0.91 | CTSL (0.41) | CTSBCTSLCYP2D6CYP2C9CCR3 | |
| SCHEMBL6699255 | 0.90 | CTSL (0.40) | CTSBCTSLCYP2D6CYP2C9CCR3 | |
| SCHEMBL6294795 | 0.89 | CTSB (0.49) | CTSBCTSLNPC1HPGDKMT2A | |
| SCHEMBL6294822 | 0.89 | CTSB (0.49) | CTSBCTSLNPC1HPGDKMT2A | |
| SCHEMBL6294295 | 0.88 | CTSL (0.40) | CTSLCYP2D6CYP2C9CCR3PPARG | |
| SCHEMBL6294793 | 0.88 | CTSB (0.45) | CTSBCTSLNPC1HPGDKMT2A | |
| SCHEMBL6991868 | 0.86 | CTSL (0.39) | CTSBCTSLCYP2D6CYP2C9KMT2A | |
| SCHEMBL6701575 | 0.85 | TRPV1 (0.44) | CTSLCYP2D6CYP2C9KLKB1 | |
| SCHEMBL6700741 | 0.84 | DRD2 (0.45) | CTSBCTSLCYP2D6CYP2C9CTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040106805-A1 | Inhibitors of cruzipain and other cysteine proteases | AMURA THERAPEUTICS LIMITED (GB) | 2004-06-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040106805-A1 | Inhibitors of cruzipain and other cysteine proteases | CTRL, CPN1, CPA1 | CTSB 33/4885CTSL 15/4885CYP2D6 4431/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.