Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 1/20 | 0.55 |
| ▸ | KDR | P35968 | 8/20 | 0.47 |
| ▸ | PLK1 | P53350 | 8/20 | 0.47 |
| ▸ | IGF1R | P08069 | 1/20 | 0.44 |
| ▸ | INSR | P06213 | 1/20 | 0.43 |
| ▸ | WEE1 | P30291 | 1/20 | 0.42 |
| ▸ | IKBKB | O14920 | 1/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.41 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.41 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.41 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.41 |
| ▸ | CDK1 | P06493 | 3/20 | 0.40 |
| ▸ | CDK4 | P11802 | 3/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.40 |
| ▸ | CCND3 | P30281 | 3/20 | 0.40 |
| ▸ | CDK6 | Q00534 | 3/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6999593 | 0.87 | FYN (0.55) | FYNKDRPLK1IGF1RINSR | |
| SCHEMBL6991975 | 0.86 | FYN (0.62) | FYNKDRPLK1IGF1RWEE1 | |
| SCHEMBL7231388 | 0.80 | FYN (0.61) | FYNKDRPLK1IGF1RINSR | |
| SCHEMBL7232580 | 0.80 | KDR (0.63) | FYNKDRPLK1IGF1RINSR | |
| SCHEMBL6999470 | 0.77 | FYN (0.60) | FYNKDRPLK1IGF1RINSR | |
| SCHEMBL7235872 | 0.77 | FYN (0.59) | FYNKDRPLK1IGF1RINSR | |
| SCHEMBL7233573 | 0.77 | FYN (0.57) | FYNKDRPLK1IGF1RINSR | |
| SCHEMBL7241122 | 0.76 | FYN (0.65) | FYNKDRPLK1IGF1RINSR | |
| Hydrochloric Acid SCHEMBL6997490 | 0.76 | FYN (0.59) | FYNKDRPLK1CDK1CDK4 | |
| Hydrochloric Acid SCHEMBL7234439 | 0.76 | FYN (0.57) | FYNKDRPLK1IGF1RINSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0989985-B1 | FUSED POLYCYCLIC 2-AMINOPYRIMIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | CELLTECH THERAPEUTICS LTD (GB) | 2003-11-05 | — | — | EP | disclosed |
| US-6133257-A | Fused polycyclic 2-aminopyrimidine derivatives | CELLTECH THERAPEUTICS LIMITED (GB) | 2000-10-17 | — | — | US | disclosed |