Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 6/20 | 0.64 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.51 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.48 |
| ▸ | BRD4 | O60885 | 2/20 | 0.48 |
| ▸ | CNR1 | P21554 | 2/20 | 0.47 |
| ▸ | BRD2 | P25440 | 1/20 | 0.47 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.47 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MME | P08473 | 1/20 | 0.45 |
| ▸ | ACE | P12821 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6991981 | 0.84 | CNR2 (0.56) | CNR2RAB9ANPC1SCN3ABRD4 | |
| SCHEMBL6988747 | 0.83 | CNR2 (0.55) | CNR2RAB9ANPC1SCN3ABRD4 | |
| SCHEMBL6993812 | 0.82 | NPC1 (0.47) | CNR2RAB9ANPC1BRD4MAPT | |
| SCHEMBL9037906 | 0.80 | NPC1 (0.48) | CNR2RAB9ANPC1MAPT | |
| SCHEMBL9037774 | 0.78 | NPSR1 (0.47) | CNR2RAB9ANPC1CNR1SMN1; SMN2 | |
| SCHEMBL1607395 | 0.76 | CNR2 (0.57) | CNR2RAB9ASCN3ABRD4BRD2 | |
| SCHEMBL6988127 | 0.76 | RAB9A (0.68) | RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL14817322 | 0.75 | KDM4E (0.71) | CNR2RAB9ASCN3ABRD4CNR1 | |
| SCHEMBL13505633 | 0.74 | CNR2 (0.72) | CNR2RAB9ANPC1CNR1SMN1; SMN2 | |
| SCHEMBL5252962 | 0.73 | CNR2 (0.55) | CNR2RAB9ASCN3ABRD4CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0557526-B1 | PYRROLOAZEPINE COMPOUND | SUNTORY LTD (JP) | 2003-04-02 | — | — | EP | disclosed |
| EP-0551527-B1 | PYRROLOAZEPINE DERIVATIVE | SUNTORY LTD (JP) | 2003-04-02 | — | — | EP | disclosed |
| EP-0441349-B1 | Pyrroloazepine derivatives | SUNTORY LTD (JP) | 1996-01-03 | — | — | EP | disclosed |
| US-5416082-A | Antiserotonine agents | SUNTORY LIMITED (JP) | 1995-05-16 | — | — | US | disclosed |
| US-5399557-A | Cardiovascular disorders | SUNTORY LIMITED (JP) | 1995-03-21 | — | — | US | disclosed |
| US-5397780-A | Antiserotonine, hypotensive, congestive heart failure | SUNTORY LIMITED (JP) | 1995-03-14 | — | — | US | disclosed |
| US-5391731-A | Useful therapeutics for circulatory diseases | SUNTORY LIMITED (JP) | 1995-02-21 | — | — | US | disclosed |
| EP-0557526-A1 | PYRROLOAZEPINE COMPOUND | SUNTORY LIMITED (JP) | 1993-09-01 | — | — | EP | disclosed |
| EP-0551527-A1 | PYRROLOAZEPINE DERIVATIVE | SUNTORY LIMITED (JP) | 1993-07-21 | — | — | EP | disclosed |
| US-5206239-A | Cardiovascular disorders | SUNTORY LIMITED (JP) | 1993-04-27 | — | — | US | disclosed |
| EP-0441349-A1 | Pyrroloazepine derivatives | SUNTORY LIMITED (JP) | 1991-08-14 | — | — | EP | disclosed |