Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | CDK4 | P11802 | 4/20 | 0.41 |
| ▸ | CCND1 | P24385 | 4/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HSD17B2 | P37059 | 3/20 | 0.40 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.40 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | PPARD | Q03181 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27592907 | 0.90 | PPARG (0.41) | PPARGMEN1KMT2AATMCDK4 | |
| SCHEMBL7523244 | 0.88 | FFAR1 (0.43) | PPARGCDK4CCND1FFAR1HSD17B2 | |
| SCHEMBL5760347 | 0.86 | FFAR1 (0.47) | PPARGFFAR1ALDH1A1CA2 | |
| SCHEMBL6185090 | 0.84 | FFAR1 (0.52) | PPARGMEN1KMT2AFFAR1ALDH1A1 | |
| SCHEMBL5399098 | 0.80 | FFAR1 (0.59) | PPARGFFAR1HSD17B2HSD17B1 | |
| SCHEMBL27599883 | 0.80 | FFAR1 (0.44) | PPARGFFAR1CA2HTR2C | |
| SCHEMBL5761010 | 0.79 | CA2 (0.49) | PPARGMEN1KMT2AFFAR1ALDH1A1 | |
| SCHEMBL6184172 | 0.78 | FFAR1 (0.59) | PPARGMEN1KMT2AFFAR1HSD17B2 | |
| SCHEMBL6986558 | 0.78 | FFAR1 (0.41) | PPARGFFAR1CA2 | |
| SCHEMBL6620937 | 0.78 | PPARG (0.44) | PPARGFFAR1CA2LIMK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1309575-A1 | BIPHENYL DERIVATIVES AND THEIR USE AS PPAR-GAMMA RECEPTOR ACTIVATORS | Galderma Research & Development (FR) | 2003-05-14 | — | — | EP | claimed |
| WO-2002012210-A1 | BIPHENYL DERIVATIVES AND THEIR USE AS PPAR-GAMMA RECEPTOR ACTIVATORS | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2002-02-14 | — | — | WO | claimed |