Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL287063 | 0.98 | L3MBTL1 (0.60) | L3MBTL1ALDH1A1POLBTDP1NPSR1 | |
| SCHEMBL22290177 | 0.83 | L3MBTL1 (0.53) | L3MBTL1ALDH1A1POLBTDP1NPSR1 | |
| SCHEMBL7108131 | 0.83 | CASP3 (0.43) | L3MBTL1ALDH1A1POLBTDP1NPSR1 | |
| SCHEMBL27999275 | 0.81 | SMN1; SMN2 (0.42) | L3MBTL1ALDH1A1TDP1NPSR1KMT2A | |
| SCHEMBL28274818 | 0.80 | CTNNB1 (0.42) | L3MBTL1ALDH1A1TDP1NPSR1HTT | |
| SCHEMBL17781263 | 0.80 | L3MBTL1 (0.47) | L3MBTL1ALDH1A1POLBNPSR1ALOX15 | |
| SCHEMBL69177 | 0.79 | L3MBTL1 (0.64) | L3MBTL1ALDH1A1POLBTDP1NPSR1 | |
| SCHEMBL1495328 | 0.79 | BRD4 (0.60) | L3MBTL1ALDH1A1NPSR1CYP1A2KMT2A | |
| SCHEMBL2414354 | 0.79 | POLB (0.44) | L3MBTL1ALDH1A1POLBTDP1 | |
| SCHEMBL31636805 | 0.79 | L3MBTL1 (0.46) | L3MBTL1ALDH1A1POLBTDP1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421850-A1 | 3 -AZABICYCLO [4.1.0]HEPTANES USED AS OREXIN ANTAGONISTS | Glaxo Group Limited (GB) | 2012-02-29 | — | — | EP | disclosed |
| WO-2010122151-A1 | 3 -AZABICYCLO [4.1.0] HEPTANES USED AS OREXIN ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2010-10-28 | — | — | WO | disclosed |