Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | TAAR1 | Q96RJ0 | 5/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.53 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.53 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.53 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.53 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.53 |
| ▸ | BCHE | P06276 | 1/20 | 0.50 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | HTR1A | P08908 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.49 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6993752 | 0.91 | GAA (0.53) | GAATAAR1LMNACYP2D6ADRA2A | |
| SCHEMBL7000055 | 0.90 | GAA (0.51) | GAATAAR1LMNACYP2D6ADRA2A | |
| SCHEMBL230024 | 0.78 | GAA (0.78) | GAALMNATSHRBCHEDDAH1 | |
| SCHEMBL6998141 | 0.76 | GAA (0.49) | GAALMNATSHRBCHEDDAH1 | |
| SCHEMBL6994270 | 0.74 | DDAH1 (0.49) | GAALMNATSHRBCHEDDAH1 | |
| Hydrochloric Acid SCHEMBL7230476 | 0.73 | DDAH1 (0.48) | GAALMNACYP2D6TSHRCYP1A2 | |
| Iodomethane SCHEMBL27491515 | 0.73 | GAA (0.70) | GAALMNATSHRBCHEDDAH1 | |
| SCHEMBL8952772 | 0.73 | KDM4E (0.58) | GAALMNACYP2D6TSHRCYP1A2 | |
| SCHEMBL6994631 | 0.72 | GAA (0.51) | GAALMNATSHRDDAH1POLB | |
| SCHEMBL6993819 | 0.72 | DDAH1 (0.54) | GAALMNATSHRBCHEDDAH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1189889-B1 | COMPOSITIONS AND METHODS FOR INHIBITING CELL DEATH | ELAN PHARMA INT LTD (IE) | 2003-12-17 | — | — | EP | claimed |
| EP-1189889-B1 | COMPOSITIONS AND METHODS FOR INHIBITING CELL DEATH | ELAN PHARMA INT LTD (IE) | 2003-12-17 | — | — | EP | disclosed |
| US-6541486-B1 | Used for treating ischemia, such as results from stroke or myocardial infarction, trauma, neurodegeneration, and inflammation. | ELAN PHARMA INTERNATIONAL LTD. (IE) | 2003-04-01 | — | — | US | disclosed |