Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | HRH1 | P35367 | 7/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | DRD1 | P21728 | 4/20 | 0.47 |
| ▸ | DRD4 | P21917 | 3/20 | 0.47 |
| ▸ | DRD5 | P21918 | 3/20 | 0.47 |
| ▸ | DRD3 | P35462 | 3/20 | 0.47 |
| ▸ | DRD2 | P14416 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL6998099 | 1.00 | KDM4E (0.48) | KDM4EL3MBTL1HRH1MEN1KMT2A | |
| Oxalic Acid SCHEMBL6992367 | 1.00 | KDM4E (0.48) | KDM4EL3MBTL1HRH1MEN1KMT2A | |
| SCHEMBL8561183 | 0.95 | HRH1 (0.51) | KDM4EL3MBTL1HRH1MEN1KMT2A | |
| SCHEMBL6993677 | 0.95 | HRH1 (0.51) | KDM4EL3MBTL1HRH1MEN1KMT2A | |
| SCHEMBL6993882 | 0.95 | HRH1 (0.51) | KDM4EL3MBTL1HRH1MEN1KMT2A | |
| SCHEMBL6993670 | 0.95 | HRH1 (0.51) | KDM4EL3MBTL1HRH1MEN1KMT2A | |
| Oxalic Acid SCHEMBL6991632 | 0.86 | ALDH1A1 (0.60) | KDM4EL3MBTL1MEN1KMT2AALDH1A1 | |
| Oxalic Acid SCHEMBL6991637 | 0.86 | ALDH1A1 (0.60) | KDM4EL3MBTL1MEN1KMT2AALDH1A1 | |
| Oxalic Acid SCHEMBL6996118 | 0.86 | MEN1 (0.43) | KDM4EL3MBTL1MEN1KMT2AALDH1A1 | |
| Oxalic Acid SCHEMBL6994123 | 0.86 | MEN1 (0.43) | KDM4EL3MBTL1MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0853615-B1 | PIPERIDINE COMPOUNDS AS CALCIUM CHANNEL BLOCKERS | NEUROSEARCH AS (DK) | 2003-12-10 | — | — | EP | disclosed |
| US-5981539-A | TREATMENT OF STROKE, ANOXIA, ISCHEMIA, MIGRAINE, PSYCHOSIS, EPILEPSY OR ANY OTHER CONVULSIVE DISORDER | NEUROSEARCH A/S (DK) | 1999-11-09 | — | — | US | disclosed |