Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 6/20 | 0.47 |
| ▸ | ESR2 | Q92731 | 5/20 | 0.47 |
| ▸ | MMP3 | P08254 | 1/20 | 0.40 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CASP6 | P55212 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | TNKS | O95271 | 1/20 | 0.35 |
| ▸ | GUSB | P08236 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.33 |
| ▸ | BCR | P11274 | 1/20 | 0.33 |
| ▸ | CDK4 | P11802 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL718222 | 0.84 | ALDH1A1 (0.41) | ESR1ESR2MEN1KMT2APOLB | |
| SCHEMBL14977497 | 0.81 | HSD17B10 (0.40) | MEN1KMT2APOLBGAATDP1 | |
| SCHEMBL1879217 | 0.81 | NR4A2 (0.47) | PTGS2MEN1KMT2AGAATNKS | |
| SCHEMBL6721218 | 0.78 | IMPDH2 (0.47) | MEN1KMT2APARP1ALDH1A1HPGD | |
| SCHEMBL7781750 | 0.75 | HTR2B (0.42) | ESR1ESR2 | |
| SCHEMBL127256 | 0.71 | ALDH1A1 (0.40) | ESR1ESR2MEN1KMT2APOLB | |
| SCHEMBL16935295 | 0.70 | ALDH1A1 (0.39) | ESR1ESR2MEN1KMT2APOLB | |
| SCHEMBL2400444 | 0.70 | AHR (0.43) | MEN1KMT2APOLBALDH1A1HPGD | |
| SCHEMBL4389405 | 0.70 | AKT2 (0.47) | — | |
| SCHEMBL4309887 | 0.68 | PARP1 (0.36) | MEN1KMT2AGAATDP1PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0819120-B1 | TRICYCLIC COMPOUNDS USEFUL FOR INHIBITION OF FARNESYL PROTEIN TRANSFERASE | SCHERING CORP (US) | 2003-06-04 | — | — | EP | disclosed |