Sugi Predict

Sugi Predict / Compounds / SCHEMBL127256

SCHEMBL127256

SCHEMBL127256

Oc1[c][nH]c2ccccc12

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 5/20 0.40
▸ GPR3 P46089 1/20 0.40
▸ HSD17B10 Q99714 1/20 0.40
▸ KDM4E B2RXH2 4/20 0.38
▸ MAPT P10636 4/20 0.38
▸ CACNA1B Q00975 2/20 0.38
▸ APBA1 Q02410 2/20 0.38
▸ IDE P14735 1/20 0.38
▸ MPI P34949 1/20 0.38
▸ IMPDH2 P12268 1/20 0.38
▸ IMPDH1 P20839 1/20 0.38
▸ IDO1 P14902 1/20 0.36
▸ GAA P10253 3/20 0.34
▸ AHR P35869 1/20 0.34
▸ LMNA P02545 1/20 0.34
▸ GLA P06280 1/20 0.34
▸ HPGD P15428 1/20 0.34
▸ HTT P42858 1/20 0.34
▸ ATM Q13315 1/20 0.34
▸ SMN1; SMN2 Q16637 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL546371 0.71 CYP1A2 (0.42) ALDH1A1GPR3HSD17B10KDM4EMAPT
SCHEMBL2987901 0.71 ALDH1A1 (0.40) ALDH1A1GPR3HSD17B10KDM4EMAPT
SCHEMBL570354 0.71 ALDH1A1 (0.40) ALDH1A1GPR3HSD17B10KDM4EMAPT
SCHEMBL650736 0.71 KDM4E (0.41) ALDH1A1GPR3HSD17B10KDM4EMAPT
SCHEMBL2073631 0.71 ALDH1A1 (0.40) ALDH1A1GPR3HSD17B10KDM4EMAPT
SCHEMBL1639050 0.71 ALDH1A1 (0.40) ALDH1A1GPR3HSD17B10KDM4EMAPT
SCHEMBL9723837 0.71 ALDH1A1 (0.40) ALDH1A1GPR3HSD17B10KDM4EMAPT
SCHEMBL3849040 0.71 ALDH1A1 (0.40) ALDH1A1GPR3HSD17B10KDM4EMAPT
SCHEMBL6992376 0.71 ESR1 (0.47) ALDH1A1HSD17B10GAAHPGDSMN1; SMN2
SCHEMBL5327645 0.71 ALDH1A1 (0.36) ALDH1A1GPR3HSD17B10KDM4EMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 209 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110713588-B Hardmask composition, hardmask layer and method of forming pattern 三星SDI株式会社 2022-08-09 — — CN claimed
CN-110713588-A Hardmask composition, hardmask layer and method of forming pattern 三星SDI株式会社 2020-01-21 — — CN claimed
EP-2428577-B1 Preparation of tyrosinase-inhibiting hydroxybenzyl and hydroxypyranonemethyl esters EASTMAN CHEM CO (US) 2014-01-22 — — EP claimed
EP-2428577-A1 Preparation of tyrosinase-inhibiting hydroxybenzyl and hydroxypyranonemethyl esters EASTMAN CHEMICAL COMPANY (US) 2012-03-14 — — EP claimed
US-20110129430-A1 HYDROXYBENZYL OR HYDROXYPYRANONEMETHYL ESTERS AS TYROSINASE INHIBITORS EASTMAN CHEMICAL COMPANY (US) 2011-06-02 — — US claimed
EP-2155886-A2 HYDROXYBENZYL OR HYDROXYPYRANONEMETHYL ESTERS AS TYROSINASE INHIBITORS Eastman Chemical Company (US) 2010-02-24 — — EP claimed
WO-2008153784-A2 HYDROXYBENZYL OR HYDROXYPYRANONEMETHYL ESTERS AS TYROSINASE INHIBITORS EASTMAN CHEMICAL COMPANY (US) 2008-12-18 — — WO claimed
US-20080306144-A1 Hydroxybenzyl or hydroxypyranonemethyl esters as tyrosinase inhibitors EASTMAN CHEMICAL COMPANY 2008-12-11 — — US claimed
WO-2008143777-A1 HYDROQUINONE DERIVATIVE SKIN BRIGHTENING COMPOUNDS EASTMAN CHEMICAL COMPANY (US) 2008-11-27 — — WO claimed
US-20080286219-A1 Hydroquinone derivative skin brightening compounds EASTMAN CHEMICAL COMPANY 2008-11-20 — — US claimed
US-5124328-A Animal growth antidepressants regulators MERCK & CO., INC. (US) 1992-06-23 — — US claimed
US-5077290-A Animal growth regulators, bronchodilators, antidepressants and antiobesity agents MERCK & CO., INC. (US) 1991-12-31 — — US claimed
EP-3632910-B1 3,4-DIHYDROQUINOLINONES AS FXR RECEPTOR AGONISTS CSPC ZHONGQI PHARMACEUTICAL TECH SHIJIAZHUANG CO LTD (CN) 2024-07-17 — — EP disclosed
WO-2023217232-A1 KINESIN KIF18A INHIBITOR AND USE THEREOF 上海湃隆生物科技有限公司 2023-11-16 — — WO disclosed
CN-110023334-B anti-GP 73 antibodies and immunoconjugates 科雅博有限责任公司 2023-11-14 — — CN disclosed
EP-4249479-A1 GLUCOSIDE DERIVATIVE, AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF Beijing Increase Innovative Drug Co., Ltd. (CN) 2023-09-27 — — EP disclosed
WO-1999001421-A1 2-(4-BROMO OR 4-IODO PHENYLAMINO) BENZOIC ACID DERIVATIVES AND THEIR USE AS MEK INHIBITORS WARNER-LAMBERT COMPANY (US) 1999-01-14 — — WO disclosed
WO-1999001426-A1 4-BROMO OR 4-IODO PHENYLAMINO BENZHYDROXAMIC ACID DERIVATIVES AND THEIR USE AS MEK INHIBITORS WARNER-LAMBERT COMPANY (US) 1999-01-14 — — WO disclosed
EP-0125118-B1 COLORIMETRIC IMMUNOASSAY ON SOLID SURFACE, DIPSTICK THEREFOR AND ITS PREPARATION QUIDEL CORPORATION (US) 1992-09-16 — — EP disclosed
EP-0125118-A2 Colorimetric immunoassay on solid surface, dipstick therefor and its preparation QUIDEL CORPORATION (US) 1984-11-14 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080306144-A1 Hydroxybenzyl or hydroxypyranonemethyl esters as tyrosinase inhibitors TYR, TH, HAAO ALDH1A1 428/4885GPR3 2657/4885HSD17B10 155/4885
US-20110129430-A1 HYDROXYBENZYL OR HYDROXYPYRANONEMETHYL ESTERS AS TYROSINASE INHIBITORS TYR, TH, HAAO ALDH1A1 428/4885GPR3 2657/4885HSD17B10 155/4885
US-20080286219-A1 Hydroquinone derivative skin brightening compounds NQO1, CUTA, TYR ALDH1A1 217/4885GPR3 3709/4885HSD17B10 480/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.