Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A15 | Q9H2J7 | 12/20 | 0.77 |
| ▸ | HRH1 | P35367 | 10/20 | 0.77 |
| ▸ | MEN1 | O00255 | 1/20 | 0.77 |
| ▸ | NPC1 | O15118 | 1/20 | 0.77 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.77 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.77 |
| ▸ | GMNN | O75496 | 1/20 | 0.77 |
| ▸ | USP2 | O75604 | 1/20 | 0.77 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.77 |
| ▸ | LMNA | P02545 | 1/20 | 0.77 |
| ▸ | TP53 | P04637 | 1/20 | 0.77 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.77 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.77 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.77 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.77 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.77 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.77 |
| ▸ | MAPT | P10636 | 1/20 | 0.77 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.77 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9373907 | 0.88 | PTAFR (0.74) | SLC6A15HRH1FNTAFNTBPTAFR | |
| Loratadine SCHEMBL4596 | 0.87 | SLC6A15 (1.00) | SLC6A15HRH1MEN1NPC1CACNA1F | |
| Loratadine SCHEMBL29380223 | 0.87 | SLC6A15 (1.00) | SLC6A15HRH1MEN1NPC1CACNA1F | |
| Loratadine SCHEMBL29441811 | 0.87 | SLC6A15 (1.00) | SLC6A15HRH1MEN1NPC1CACNA1F | |
| Loratadine SCHEMBL3862958 | 0.87 | SLC6A15 (1.00) | SLC6A15HRH1MEN1NPC1CACNA1F | |
| SCHEMBL6996228 | 0.87 | FNTA (0.67) | SLC6A15HRH1MEN1NPC1CACNA1F | |
| SCHEMBL6999044 | 0.87 | SLC6A15 (0.63) | SLC6A15HRH1MEN1NPC1CACNA1F | |
| SCHEMBL7000779 | 0.87 | SLC6A15 (0.63) | SLC6A15HRH1MEN1NPC1CACNA1F | |
| SCHEMBL12065129 | 0.87 | HRH1 (0.61) | SLC6A15HRH1MEN1NPC1CACNA1F | |
| Loratadine SCHEMBL21529218 | 0.86 | SLC6A15 (0.98) | SLC6A15HRH1MEN1NPC1CACNA1F |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1021448-B1 | TRICYCLIC COMPOUNDS HAVING ACTIVITY AS Ras-FPT INHIBITORS | SCHERING CORP (US) | 2003-05-02 | — | — | EP | disclosed |
| US-6130229-A | Tricyclic compounds having activity as RAS-FPT inhibitors | SCHERING CORPORATION (US) | 2000-10-10 | — | — | US | disclosed |
| EP-1021448-A1 | TRICYCLIC COMPOUNDS HAVING ACTIVITY AS Ras-FPT INHIBITORS | SCHERING CORPORATION (US) | 2000-07-26 | — | — | EP | disclosed |
| WO-1998015556-A1 | TRICYCLIC COMPOUNDS HAVING ACTIVITY AS Ras-FPT INHIBITORS | SCHERING CORPORATION (US) | 1998-04-16 | — | — | WO | disclosed |
| EP-0535152-B1 | Bis-benzo or benzopyrido cyclo hepta piperidene, piperidylene and piperazine compounds as PAF antagonists and compositions thereof. | SCHERING CORP (US) | 1995-08-09 | — | — | EP | disclosed |
| US-5422351-A | Antiallergens; antiinflammatory agents | SCHERING CORPORATION (US) | 1995-06-06 | — | — | US | disclosed |
| EP-0341860-B1 | Benzopyrido piperidine, piperidylidene and piperazine compounds, compositions, methods of manufacture and methods of use | SCHERING CORP (US) | 1994-07-13 | — | — | EP | disclosed |
| EP-0586560-A1 | NOVEL BENZOPYRIDO PIPERIDYLIDENE COMPOUNDS, COMPOSITIONS, METHODS OF MANUFACTURE AND METHODS OF USE | SCHERING CORPORATION (US) | 1994-03-16 | — | — | EP | disclosed |
| WO-1992020681-A1 | NOVEL BENZOPYRIDO PIPERIDYLIDENE COMPOUNDS, COMPOSITIONS, METHODS OF MANUFACTURE AND METHODS OF USE | SCHERING CORPORATION (US) | 1992-11-26 | — | — | WO | disclosed |
| EP-0515158-A1 | Novel benzopyrido piperidylidene compounds, compositions, methods of manufacture and methods of use | SCHERING CORPORATION (US) | 1992-11-25 | — | — | EP | disclosed |
| US-5104876-A | Antiallergens, antiinflammatory agent | SCHERING CORPORATION | 1992-04-14 | — | — | US | disclosed |
| EP-0411048-A1 | NOVEL BENZOPYRIDO PIPERIDINE, PIPERIDYLIDENE AND PIPERAZINE COMPOUNDS, COMPOSITIONS, METHODS OF MANUFACTURE AND METHODS OF USE | SCHERING CORPORATION (US) | 1991-02-06 | — | — | EP | disclosed |
| EP-0341860-A1 | Benzopyrido piperidine, piperidylidene and piperazine compounds, compositions, methods of manufacture and methods of use | SCHERING CORPORATION (US) | 1989-11-15 | — | — | EP | disclosed |
| WO-1989010369-A1 | NOVEL BENZOPYRIDO PIPERIDINE, PIPERIDYLIDENE AND PIPERAZINE COMPOUNDS, COMPOSITIONS, METHODS OF MANUFACTURE AND METHODS OF USE | SCHERING CORPORATION (US) | 1989-11-02 | — | — | WO | disclosed |