Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 6/20 | 0.39 |
| ▸ | DRD3 | P35462 | 6/20 | 0.39 |
| ▸ | HTR1A | P08908 | 12/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 10/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 9/20 | 0.39 |
| ▸ | HTR1B | P28222 | 9/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 9/20 | 0.39 |
| ▸ | HTR7 | P34969 | 3/20 | 0.37 |
| ▸ | DRD4 | P21917 | 2/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 3/20 | 0.37 |
| ▸ | DRD1 | P21728 | 1/20 | 0.36 |
| ▸ | DRD5 | P21918 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6992089 | 0.94 | HTR1A (0.41) | DRD2DRD3HTR1AADRA1AADRA1D | |
| SCHEMBL6993895 | 0.86 | HRH3 (0.38) | DRD2DRD3HTR1AADRA1AADRA1D | |
| SCHEMBL6989795 | 0.85 | HTR1A (0.52) | DRD2DRD3HTR1AADRA1AADRA1D | |
| SCHEMBL6995968 | 0.85 | HTR1A (0.51) | DRD2DRD3HTR1AADRA1AADRA1D | |
| SCHEMBL6998070 | 0.84 | HTR1A (0.44) | DRD2DRD3HTR1AADRA1AADRA1D | |
| SCHEMBL6989660 | 0.84 | HTR1A (0.42) | DRD2DRD3HTR1AADRA1AADRA1D | |
| SCHEMBL6994228 | 0.83 | HTR1A (0.48) | DRD2DRD3HTR1AADRA1AADRA1D | |
| SCHEMBL6993063 | 0.83 | HTR1A (0.41) | DRD2DRD3HTR1AADRA1AADRA1D | |
| SCHEMBL6993375 | 0.83 | OPRM1 (0.43) | DRD2DRD3HTR1AADRA1AADRA1D | |
| SCHEMBL7092290 | 0.83 | HTR1A (0.53) | DRD2DRD3HTR1AADRA1AADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0927184-B1 | 3-SUBSTITUTED PYRIDO 4',3':4,5]THIENO 2,3-D]PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE | ABBOTT GMBH & CO KG (DE) | 2003-10-22 | — | — | EP | disclosed |