Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 12/20 | 0.52 |
| ▸ | ADRA1D | P25100 | 11/20 | 0.52 |
| ▸ | ADRA1A | P35348 | 11/20 | 0.52 |
| ▸ | ADRA1B | P35368 | 11/20 | 0.52 |
| ▸ | HTR1B | P28222 | 10/20 | 0.52 |
| ▸ | DRD2 | P14416 | 2/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6995968 | 0.91 | HTR1A (0.51) | HTR1AADRA1DADRA1AADRA1BHTR1B | |
| SCHEMBL6998070 | 0.91 | HTR1A (0.44) | HTR1AADRA1DADRA1AADRA1BHTR1B | |
| SCHEMBL6989660 | 0.91 | HTR1A (0.42) | HTR1AADRA1DADRA1AADRA1BHTR1B | |
| SCHEMBL7092290 | 0.89 | HTR1A (0.53) | HTR1AADRA1DADRA1AADRA1BHTR1B | |
| SCHEMBL6993063 | 0.89 | HTR1A (0.41) | HTR1AADRA1DADRA1AADRA1BHTR1B | |
| SCHEMBL6997280 | 0.88 | HTR1A (0.53) | HTR1AADRA1DADRA1AADRA1BHTR1B | |
| SCHEMBL6994228 | 0.88 | HTR1A (0.48) | HTR1AADRA1DADRA1AADRA1BHTR1B | |
| SCHEMBL6991651 | 0.87 | HTR1A (0.41) | HTR1AADRA1DADRA1AADRA1BHTR1B | |
| SCHEMBL6992477 | 0.85 | DRD2 (0.39) | HTR1AADRA1DADRA1AADRA1BHTR1B | |
| SCHEMBL6989308 | 0.84 | ADRA1D (0.57) | HTR1AADRA1DADRA1AADRA1BHTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0927184-B1 | 3-SUBSTITUTED PYRIDO 4',3':4,5]THIENO 2,3-D]PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE | ABBOTT GMBH & CO KG (DE) | 2003-10-22 | — | — | EP | disclosed |