Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | FNTA | P49354 | 2/20 | 0.36 |
| ▸ | FNTB | P49356 | 2/20 | 0.36 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.35 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 5/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6992704 | 0.88 | PDPK1 (0.45) | FNTAFNTBPDPK1OPRL1KCNH2 | |
| SCHEMBL5425623 | 0.78 | PDPK1 (0.53) | HDAC1HDAC6PDPK1OPRL1KCNH2 | |
| SCHEMBL6997518 | 0.78 | HTR2A (0.44) | PDPK1CYP2D6 | |
| Hydrochloric Acid SCHEMBL18764973 | 0.77 | PDPK1 (0.51) | HDAC1HDAC6PDPK1OPRL1KCNH2 | |
| SCHEMBL20840606 | 0.76 | P2RX7 (0.36) | HDAC1HDAC6PDPK1TRPM8OPRL1 | |
| SCHEMBL3081802 | 0.75 | HDAC1 (0.50) | HDAC1HDAC6PDPK1CYP2D6 | |
| SCHEMBL4891510 | 0.75 | HDAC1 (0.50) | HDAC1HDAC6PDPK1CYP2D6 | |
| SCHEMBL3088474 | 0.75 | HDAC1 (0.50) | HDAC1HDAC6PDPK1CYP2D6 | |
| Hydrochloric Acid SCHEMBL4890977 | 0.74 | HDAC1 (0.49) | HDAC1HDAC6PDPK1CYP2D6 | |
| SCHEMBL5426156 | 0.74 | HDAC1 (0.49) | HDAC1HDAC6PDPK1OPRL1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1069132-B1 | Bicyclic derivatives of amino-pyrazinones, process of preparation and pharmaceutical compositions comprising them | SERVIER LAB (FR) | 2003-10-01 | — | — | EP | disclosed |
| EP-1069132-A1 | Bicyclic derivatives of amino-pyrazinones, process of preparation and pharmaceutical compositions comprising them | ADIR ET COMPAGNIE (FR) | 2001-01-17 | — | — | EP | disclosed |