Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 13/20 | 0.44 |
| ▸ | HRH1 | P35367 | 10/20 | 0.44 |
| ▸ | HTR2C | P28335 | 4/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | DRD1 | P21728 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | HTR3A | P46098 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6992704 | 0.87 | PDPK1 (0.45) | HTR2AADRA1APDPK1 | |
| SCHEMBL7003542 | 0.80 | HTR2A (0.57) | HTR2AHRH1HTR2CDRD3PDPK1 | |
| SCHEMBL7001701 | 0.78 | HDAC1 (0.36) | CYP2D6PDPK1 | |
| SCHEMBL6997509 | 0.71 | HTR2A (0.66) | HTR2AHRH1HTR2C | |
| SCHEMBL6998985 | 0.69 | PDPK1 (0.59) | HTR2AHRH1HTR2CADRA2ACYP2D6 | |
| Hydrochloric Acid SCHEMBL6718185 | 0.67 | PDPK1 (0.57) | HTR2AHRH1HTR2CCYP2D6CYP2C9 | |
| SCHEMBL21259170 | 0.66 | PDPK1 (0.55) | HTR2AHRH1CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL12050760 | 0.66 | FNTA (0.45) | HTR2AHTR2C | |
| SCHEMBL21259158 | 0.65 | PDPK1 (0.44) | HTR2AHRH1HTR2CADRA2ACYP2D6 | |
| SCHEMBL8241948 | 0.65 | HTR2A (0.44) | HTR2AHRH1HTR2CCYP1A2CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1069132-B1 | Bicyclic derivatives of amino-pyrazinones, process of preparation and pharmaceutical compositions comprising them | SERVIER LAB (FR) | 2003-10-01 | — | — | EP | disclosed |
| EP-1069132-A1 | Bicyclic derivatives of amino-pyrazinones, process of preparation and pharmaceutical compositions comprising them | ADIR ET COMPAGNIE (FR) | 2001-01-17 | — | — | EP | disclosed |