SCHEMBL6992749

SCHEMBL6992749

[c]1c(-c2csc3ccccc23)sc2ccccc12

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 3/20 0.38
CHRM2 P08172 1/20 0.38
CHRM4 P08173 1/20 0.38
CHRM5 P08912 1/20 0.38
CHRM1 P11229 1/20 0.38
CHRM3 P20309 1/20 0.38
MAPT P10636 1/20 0.37
ERN1 O75460 3/20 0.36
GPR3 P46089 1/20 0.34
ALDH1A1 P00352 3/20 0.34
KDM1A O60341 1/20 0.34
HDAC3 O15379 1/20 0.33
HDAC4 P56524 1/20 0.33
HDAC1 Q13547 1/20 0.33
HDAC7 Q8WUI4 1/20 0.33
HDAC2 Q92769 1/20 0.33
HDAC10 Q969S8 1/20 0.33
HDAC11 Q96DB2 1/20 0.33
HDAC8 Q9BY41 1/20 0.33
HDAC6 Q9UBN7 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4381193 0.74 CYP2A6 (0.54) CYP2A6CHRM2CHRM4CHRM5CHRM1
SCHEMBL6885688 0.72 MIF (0.35) CHRM2CHRM4CHRM5CHRM1CHRM3
SCHEMBL2965431 0.70 ALDH1A1 (0.33) GPR3ALDH1A1
SCHEMBL28581187 0.68 NPC1 (0.43) MAPTALDH1A1HPGDLMNAHTT
SCHEMBL15460256 0.68 ERN1 (0.41) CYP2A6CHRM2CHRM4CHRM5CHRM1
SCHEMBL5987950 0.68 KDM4E (0.42) CYP2A6MAPTALDH1A1HDAC1HPGD
SCHEMBL7527660 0.68 CHRM2 (0.37) CYP2A6CHRM2CHRM4CHRM5CHRM1
SCHEMBL23555986 0.67 ERN1 (0.54) CYP2A6CHRM2CHRM4CHRM5CHRM1
SCHEMBL31092063 0.67 CYP2A6 (0.52) CYP2A6CHRM2CHRM4CHRM5CHRM1
SCHEMBL5848721 0.67 CYP2A6 (0.52) CYP2A6CHRM2CHRM4CHRM5CHRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1337520-A1 SUBSTITUTED 5-ARYL AND 5-HETEROARYL-2-(2-HYDROXYPHENYL)-2H-BENZOTRIAZOLE DERIVATIVES AS UV ABSORBERS Ciba SC Holding AG (CH) 2003-08-27 EP disclosed
WO-2002042281-A1 SUBSTITUTED 5-ARYL AND 5-HETEROARYL-2-(2-HYDROXYPHENYL)-2H-BENZOTRIAZOLE DERIVATIVES AS UV ABSORBERS CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) 2002-05-30 WO disclosed