Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 3/20 | 0.60 |
| ▸ | PLG | P00747 | 2/20 | 0.60 |
| ▸ | PLAT | P00750 | 2/20 | 0.60 |
| ▸ | PARG | Q86W56 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | CA9 | Q16790 | 5/20 | 0.43 |
| ▸ | CA1 | P00915 | 5/20 | 0.43 |
| ▸ | CA2 | P00918 | 5/20 | 0.43 |
| ▸ | CA12 | O43570 | 3/20 | 0.43 |
| ▸ | CA6 | P23280 | 3/20 | 0.43 |
| ▸ | CA5A | P35218 | 3/20 | 0.43 |
| ▸ | CA7 | P43166 | 3/20 | 0.43 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.43 |
| ▸ | CA5B | Q9Y2D0 | 3/20 | 0.43 |
| ▸ | CA4 | P22748 | 2/20 | 0.43 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.42 |
| ▸ | CA3 | P07451 | 1/20 | 0.41 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17824799 | 0.85 | PARG (0.58) | PLAUPLGPLATPARGLMNA | |
| SCHEMBL27527771 | 0.80 | PARG (0.53) | PLAUPLGPLATPARGLMNA | |
| SCHEMBL6998566 | 0.75 | PLG (0.65) | PLAUPLGPLATPARGCA9 | |
| SCHEMBL6993186 | 0.73 | PLAU (0.65) | PLAUPLGPLATCA9CA1 | |
| SCHEMBL2595325 | 0.73 | CA9 (0.50) | PLAUPLGPLATCA9CA1 | |
| Propylene Oxide SCHEMBL11889807 | 0.73 | PARG (0.53) | PLAUPLGPLATPARGLMNA | |
| SCHEMBL17825169 | 0.73 | PARG (1.00) | PARG | |
| SCHEMBL25368878 | 0.73 | MAPT (0.47) | PLAUPARGLMNACYP3A4MAPT | |
| SCHEMBL6436143 | 0.73 | PLAU (0.59) | PLAUPLGPLATPARGLMNA | |
| SCHEMBL14058906 | 0.72 | LMNA (0.56) | PLAUPLGPLATLMNACA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1023268-B1 | ISOQUINOLINES AS UROKINASE INHIBITORS | PFIZER LTD (GB) | 2003-05-21 | — | — | EP | disclosed |
| US-6248738-B1 | ANTIULCER AGENTS, ANGIOGENESIS INHIBITORS, ANTIMETASTASIS AGENTS, ANTITUMOR AGENTS | PFIZER INC. | 2001-06-19 | — | — | US | disclosed |
| CN-1275979-A | Isoquinoline compounds useful as urokinase inhibitors | PFIZER (US) | 2000-12-06 | — | — | CN | disclosed |
| EP-1023268-A1 | ISOQUINOLINES AS UROKINASE INHIBITORS | Pfizer Limited (GB) | 2000-08-02 | — | — | EP | disclosed |
| WO-1999020608-A1 | ISOQUINOLINES AS UROKINASE INHIBITORS | PFIZER LIMITED (GB) | 1999-04-29 | — | — | WO | disclosed |