Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARG | Q86W56 | 1/20 | 0.53 |
| ▸ | PLG | P00747 | 2/20 | 0.38 |
| ▸ | PLAU | P00749 | 2/20 | 0.38 |
| ▸ | PLAT | P00750 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | CASP6 | P55212 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | APEX1 | P27695 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7536983 | 0.76 | HSD17B10 (0.46) | PARGPLGPLAUPLATALDH1A1 | |
| SCHEMBL17824799 | 0.74 | PARG (0.58) | PARGPLGPLAUPLATALDH1A1 | |
| SCHEMBL6993419 | 0.73 | PLAU (0.60) | PARGPLGPLAUPLATMAPT | |
| SCHEMBL27527771 | 0.70 | PARG (0.53) | PARGPLGPLAUPLATALDH1A1 | |
| SCHEMBL17825169 | 0.69 | PARG (1.00) | PARG | |
| SCHEMBL14514049 | 0.68 | ALDH1A1 (0.62) | ALDH1A1CASP6HSD17B10CYP2C9CYP2C19 | |
| SCHEMBL29786977 | 0.67 | LMNA (0.50) | PARGALDH1A1MAPTLMNAKMT2A | |
| SCHEMBL1317870 | 0.67 | LMNA (0.50) | PARGALDH1A1MAPTLMNAKMT2A | |
| SCHEMBL6998566 | 0.66 | PLG (0.65) | PARGPLGPLAUPLATALDH1A1 | |
| SCHEMBL18691153 | 0.65 | LMNA (0.44) | PARGMAPTLMNAAPEX1HIPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2332917-B1 | Compounds for PIM kinase inhibition and for treating malignancy | SYGNIS BIOSCIENCE GMBH & CO KG (DE) | 2012-08-01 | — | — | EP | disclosed |