Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 14/20 | 0.57 |
| ▸ | MAOB | P27338 | 10/20 | 0.57 |
| ▸ | MAOA | P21397 | 7/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.52 |
| ▸ | RCOR1 | Q9UKL0 | 3/20 | 0.52 |
| ▸ | KDM1B | Q8NB78 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.50 |
| ▸ | CYP2B6 | P20813 | 3/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | HTR1A | P08908 | 1/20 | 0.50 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.50 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6993703 | 1.00 | KDM1A (0.57) | KDM1AMAOBMAOAKDM4EMAPT | |
| SCHEMBL15212423 | 0.82 | KDM1A (0.60) | KDM1AMAOBMAOAKDM4EMAPT | |
| SCHEMBL28268430 | 0.82 | CA2 (0.48) | KDM1AMAOACHRNA7 | |
| SCHEMBL28270004 | 0.82 | CHRNA7 (0.48) | KDM1AMAOACHRNA7 | |
| SCHEMBL6998779 | 0.77 | KDM1A (0.55) | KDM1AMAOBMAOAKDM4EMAPT | |
| SCHEMBL6998780 | 0.77 | KDM1A (0.55) | KDM1AMAOBMAOAKDM4EMAPT | |
| SCHEMBL18889026 | 0.76 | CA2 (0.47) | KDM1AMAOACHRNA7 | |
| SCHEMBL19378424 | 0.76 | CA2 (0.47) | CYP2C19CHRNA7 | |
| SCHEMBL19378503 | 0.76 | CA12 (0.47) | KDM1AMAOACHRNA7 | |
| SCHEMBL18888959 | 0.76 | CA2 (0.47) | KDM1AMAOACHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0996621-B1 | TRIAZOLO[4,5-d]PYRIMIDINE DERIVATIVES AS ANTI-THROMBOTIC AGENTS | ASTRAZENECA AB (SE) | 2003-10-01 | — | — | EP | disclosed |
| EP-1056749-B1 | NOVEL TRIAZOLO(4,5-d)PYRIMIDINE COMPOUNDS | ASTRAZENECA UK LTD (GB) | 2003-02-19 | — | — | EP | disclosed |
| US-6369064-B1 | MYOCARDIAL INFARCTION AND UNSTABLE ANGINA; P2T-RECEPTOR ANTAGONISTS; ANTITHROMBOTIC AGENTS; 7-(SUBSTITUTED AMINO) -5-(THIO)-3H-1,2,3-TRIAZOLO(4,5-D)PYRIMIDIN-3-YL) -CYCLOPENTANECARBOXAMIDES | ASTRAZENECA AB (SE) | 2002-04-09 | — | — | US | disclosed |
| US-6251910-B1 | 1,2,3-triazolo[4,5-d]pyrimidines as P2T receptor antagonists | ASTRAZENECA UK LIMITED (GB) | 2001-06-26 | — | — | US | disclosed |