Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.60 |
| ▸ | FLT3 | P36888 | 2/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.50 |
| ▸ | AXL | P30530 | 1/20 | 0.50 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.49 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.49 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.49 |
| ▸ | AHR | P35869 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6989977 | 0.89 | CYP1A2 (0.50) | LOXL2FLT3MTNR1APDGFRBMTNR1B | |
| SCHEMBL7415018 | 0.86 | LOXL2 (0.60) | LOXL2FLT3HRH3AXLMTNR1A | |
| SCHEMBL6989050 | 0.86 | LOXL2 (0.60) | LOXL2FLT3HRH3AXLMTNR1A | |
| SCHEMBL10443687 | 0.85 | LOXL2 (0.63) | LOXL2FLT3HRH3AXLMTNR1A | |
| SCHEMBL867547 | 0.85 | LOXL2 (0.75) | LOXL2FLT3HRH3AXLMTNR1A | |
| SCHEMBL6826452 | 0.83 | LOXL2 (0.64) | LOXL2AHRSMN1; SMN2KDM4EMEN1 | |
| SCHEMBL6995621 | 0.82 | F2 (0.55) | LOXL2FLT3KMT2A | |
| SCHEMBL9529505 | 0.81 | LOXL2 (0.48) | LOXL2SMN1; SMN2 | |
| SCHEMBL7490718 | 0.81 | IMPDH2 (0.48) | LOXL2SMN1; SMN2KDM4EMEN1KMT2A | |
| SCHEMBL6994727 | 0.81 | LOXL2 (0.57) | LOXL2SMN1; SMN2KDM4ENPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1322646-A1 | 2-(1H-INDOL-3-YL)-2-OXO-ACETIC ACID AMIDES WITH ANTITUMOR ACTIVITY | Novuspharma S.p.A. (IT) | 2003-07-02 | — | — | EP | disclosed |
| WO-2002008225-A1 | 2-(1H-INDOL-3-YL)-2-OXO-ACETIC ACID AMIDES WITH ANTITUMOR ACTIVITY | NOVUSPHARMA S.P.A. (IT) | 2002-01-31 | — | — | WO | disclosed |