Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.48 |
| ▸ | LTA4H | P09960 | 2/20 | 0.42 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 2/20 | 0.40 |
| ▸ | MAOB | P27338 | 6/20 | 0.39 |
| ▸ | MAOA | P21397 | 2/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6993755 | 0.81 | LOXL2 (0.60) | LOXL2SMN1; SMN2 | |
| SCHEMBL9534394 | 0.81 | LOXL2 (0.40) | LOXL2SIRT1F2MAOBMAOA | |
| SCHEMBL6990842 | 0.81 | MAOB (0.57) | LOXL2F2MAOBMAOABCHE | |
| SCHEMBL9529857 | 0.79 | MEN1 (0.47) | MAOBMAOASMN1; SMN2 | |
| SCHEMBL6826452 | 0.79 | LOXL2 (0.64) | LOXL2LTA4HSIRT1F2SMN1; SMN2 | |
| SCHEMBL6995621 | 0.78 | F2 (0.55) | LOXL2F2 | |
| SCHEMBL9531674 | 0.76 | PDE10A (0.46) | MAOBMAOASMN1; SMN2 | |
| SCHEMBL11428952 | 0.75 | LTA4H (0.70) | LTA4HMAOB | |
| SCHEMBL9529663 | 0.74 | PDE10A (0.51) | — | |
| SCHEMBL9530334 | 0.74 | MEN1 (0.49) | LOXL2SIRT1F2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0544821-A1 | INDOLE DERIVATIVES AS ANTIALLERGY AND ANTIINFLAMMATORY AGENTS. | PFIZER (US) | 1993-06-09 | — | — | EP | disclosed |
| WO-1992006088-A1 | INDOLE DERIVATIVES AS ANTIALLERGY AND ANTIINFLAMMATORY AGENTS | PFIZER INC. (US) | 1992-04-16 | — | — | WO | disclosed |