Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 4/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1279560 | 0.84 | CHRM2 (0.54) | CHRM2LMNAMAPTALDH1A1L3MBTL1 | |
| SCHEMBL5969220 | 0.79 | LMNA (0.55) | CHRM2LMNAMAPTALDH1A1L3MBTL1 | |
| SCHEMBL14476995 | 0.78 | CHRM2 (0.79) | CHRM2LMNAKMT2AMEN1KDM4E | |
| SCHEMBL10282552 | 0.77 | CHRM2 (0.66) | CHRM2LMNAMAPTALDH1A1L3MBTL1 | |
| SCHEMBL3136680 | 0.77 | LMNA (0.48) | CHRM2LMNAMAPTALDH1A1L3MBTL1 | |
| SCHEMBL5162780 | 0.76 | LMNA (0.59) | CHRM2LMNAMAPTALDH1A1L3MBTL1 | |
| SCHEMBL13402070 | 0.74 | LMNA (0.47) | CHRM2LMNAMAPTALDH1A1L3MBTL1 | |
| SCHEMBL8697987 | 0.74 | ALDH1A1 (0.51) | CHRM2LMNAMAPTALDH1A1L3MBTL1 | |
| SCHEMBL513576 | 0.74 | CHRM2 (0.57) | CHRM2LMNAMAPTALDH1A1L3MBTL1 | |
| SCHEMBL12851943 | 0.73 | KDM4E (0.57) | CHRM2LMNAALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012065057-A2 | PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS AND METHODS OF THEIR USE | EXELIXIS, INC. (US) | 2012-05-18 | — | — | WO | disclosed |